ArticleAntioxidants (Basel, Switzerland)2024
Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver.
Osiris Germán Idelfonso-García, Brisa Rodope Alarcón-Sánchez, Dafne Guerrero-Escalera, Norma Arely López-Hernández, José Luis Pérez-Hernández, Ruth Pacheco-Rivera, Jesús Serrano-Luna, Osbaldo Resendis-Antonio, Erick Andrés Muciño-Olmos, Diana Ivette Aparicio-Bautista and 8 more
Open access · goldAbstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
18 authors at 8 institutions in 2 countries.
Osiris Germán Idelfonso-GarcíaLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0002-5627-5164 Brisa Rodope Alarcón-SánchezLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0002-5619-3169 Dafne Guerrero-EscaleraLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.
Norma Arely López-HernándezLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.
José Luis Pérez-HernándezDepartment of Gastroenterology and Hepatology, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0003-4367-8463 Ruth Pacheco-RiveraLaboratory of Molecular Diagnostics, Department of Biochemistry, National School of Biological Sciences of the National Polytechnic Institute, Mexico City 07738, Mexico.
Jesús Serrano-LunaDepartment of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPN, Mexico City 07360, Mexico.
Osbaldo Resendis-AntonioLaboratory of Human Systems Biology, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0001-5220-541X Erick Andrés Muciño-OlmosDivision of Translational Cancer Research, Department of Laboratory Medicine, Lund University, 22381 Lund, Sweden.
Diana Ivette Aparicio-BautistaLaboratory of Genomics of Bone Metabolism, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0003-0036-7227 Gustavo Basurto-IslasDepartment of Science and Engineering, University of Guanajuato, Leon 37670, Guanajuato, Mexico.ORCID 0000-0002-9401-140X Rafael Baltiérrez-HoyosLaboratory of Fibrosis and Cancer, Faculty of Medicine and Surgery, 'Benito Juárez' Autonomous University of Oaxaca-UABJO, Oaxaca 68120, Mexico.ORCID 0000-0003-3416-6917 Verónica Rocío Vásquez-GarzónLaboratory of Fibrosis and Cancer, Faculty of Medicine and Surgery, 'Benito Juárez' Autonomous University of Oaxaca-UABJO, Oaxaca 68120, Mexico.ORCID 0000-0002-4861-8235 Saúl Villa-TreviñoDepartment of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPN, Mexico City 07360, Mexico.ORCID 0000-0002-8292-8157 Pablo MurielLaboratory of Experimental Hepatology, Department of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPN, Mexico City 07360, Mexico.ORCID 0000-0002-2236-6631 Héctor SerranoDepartment of Health Sciences, Div CBS, Metropolitan Autonomous University-Iztapalapa Campus, Mexico City 09340, Mexico.
Julio Isael Pérez-CarreónLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0001-9284-7775 Jaime Arellanes-RobledoLaboratory of Liver Diseases, National Institute of Genomic Medicine-INMEGEN, Mexico City 14610, Mexico.ORCID 0000-0001-7363-4870 National Institute of Genomic Medicine · MXCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXSecretaría de Ciencia, Humanidades, Tecnología e Innovación · MXUniversidad Autónoma Metropolitana · MXHospital General de México · MXLund University · SETecnológico Nacional de México · MXUniversidad de Guanajuato · MX
Funding
Allosteric control of monoacylglyceride lipase (MGL) activityR21DA053358 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOR, MARCO, PIOMELLI, DANIELE · 2022 to 2023
$397kCenter for Research and Advanced Studies of the National Polytechnic Institute 0114-14Consejo Nacional de Humanidades, Ciencias y Tecnologías CF2019-53358National Institute of Genomic Medicine 06/2017/I
6 · The paper itselfAbstract
Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen species and regulates key cellular processes through redox protein-protein interactions. Here, we determine the effect of chronic alcohol consumption on NXN-dependent redox interactions in the liver of aged mice. We found that chronic alcohol consumption preferentially promotes the localization of NXN either into or alongside senescent cells, declines its interacting capability, and worsens the altered interaction ratio of NXN with FLII, MYD88, CAMK2A, and PFK1 proteins induced by aging. In addition, carbonylated protein and cell proliferation increased, and the ratios of collagen I and collagen III were inverted. Thus, we demonstrate an emerging phenomenon associated with altered redox homeostasis during aging, as shown by the declining capability of NXN to interact with partner proteins, which is enhanced by chronic alcohol consumption in the mouse liver. This evidence opens an attractive window to elucidate the consequences of both aging and chronic alcohol consumption on the downstream signaling pathways regulated by NXN-dependent redox-sensitive interactions.
Indexed as
alcoholic liver diseasecellular senescenceoxidative stressprotein carbonylation
Identifiers
PMID38539791
PMCPMC10967286
OpenAlexW4391960721
What OpenQuestion holds
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LicenceCC BY
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