Evidence map›Paper›PMID 38539595›Full record

ArticleBrain sciences2024

Mirror Therapy Reduces Pain and Preserves Corticomotor Excitability in Human Experimental Skeletal Muscle Pain.

Keita Nishi, Takefumi Moriuchi, Ryohei Okamura, Takashi Hasegawa, Xiaoqian Chang, Shinichi Matsumoto, Hironobu Koseki, Toshio Higashi

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07380958 (Mirror Therapy as an Adjunct to Rehabilitation Following Total Knee Arthroplasty), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07380958 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mirror Therapy as an Adjunct to Rehabilitation Following Total Knee Arthroplasty

TypeinterventionalSponsorState University of New York - Upstate Medical UniversityRan2026 to 2026Enrolled30ConditionsTotal Knee Arthroplasty RecoveryArmsMirror Therapy, Sham Intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Keita NishiDepartment of Physical Therapy, School of Health Science, Toyohashi Sozo University, 20-1 Matsushita, Ushikawa-cho, Toyohashi 440-8511, Japan.
Takefumi MoriuchiGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Ryohei OkamuraGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Takashi HasegawaGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Xiaoqian ChangGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Shinichi MatsumotoGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Hironobu KosekiGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.ORCID 0000-0001-5047-2311
Toshio HigashiGraduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Nagasaki University · JPToyohashi Sozo College · JP

Funding

Japan Society for the Promotion of Science 21K17530
6 · The paper itself

Abstract

Approaches to preserve corticomotor excitability (CE) are attracting interest as a treatment for pain-induced changes in neural plasticity. We determined the effects of mirror therapy (MT) on skeletal muscle pain. Fifteen healthy adults who received hypertonic saline injections (5.8% NaCl, 0.2 mL) into the first dorsal interosseous (FDI) muscle of the right hand to induce experimental skeletal muscle pain were assigned to either the "MT and injection" or "injection only" group. Post-injection, the "MT and injection" group observed their left index finger abducting and adducting for 4 min, creating the illusion that the right index finger was moving. The "injection only" group remained at rest. CE and pain were assessed by measuring motor-evoked potentials (MEPs) of the right FDI triggered by transcranial magnetic stimulation and the numerical rating scale (NRS), respectively. MEP amplitudes were significantly higher in the "MT and injection" group, a trend that persisted post-MT intervention (MT intervention;

Indexed as

corticomotor excitabilityexperimental muscle painhypertonic salinemirror therapymotor-evoked potentialstranscranial magnetic stimulation

Identifiers

PMID38539595
PMCPMC10968047
OpenAlexW4392103724

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.