Evidence map›Paper›PMID 38539221›Full record

ArticleStem cell research & therapy2024

Improved therapeutic consistency and efficacy of CD317

Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma, Meiqi Li, Jingting Zhang, Lan Yao, Jianyong Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shaoquan Shi *Shenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Si Chen *Shenzhen University Medical School, Shenzhen University, Shenzhen, 518000, People's Republic of China.
Bowei Liang *Shenzhen University Medical School, Shenzhen University, Shenzhen, 518000, People's Republic of China.
Yumeng LiShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Qi MaShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Meiqi LiShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Jingting ZhangShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Lan YaoShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China.
Jianyong XuShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital, Fuqiang Avenue 1001, Shenzhen, 518060, Guangdong, People's Republic of China. xujianyong820915@163.com.ORCID 0000-0003-1910-4603
Shenzhen Zhongshan Urological Hospital · CNShenzhen University · CNSouthern University of Science and Technology · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021A1515012484Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515010181
6 · The paper itself

Abstract

backgroundPreviously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expanded with chemical defined medium have improved therapeutic consistency.

methodsIn the current study, we studied the MSC subpopulation composition and variation in different types and batches of MSC expansion medium with scRNA-seq analysis.

resultsMSCs expanded with different batches of media have higher levels of heterogeneity from the perspective of cell subpopulation composition at transcriptome levels and therapeutic inconsistency. The CD317

Indexed as

Mesenchymal Stem CellsCell DifferentiationCell ProliferationHumansSignal TransductionCD317Mesenchymal stem/stromal cellsMSCsTherapeutic consistencyTherapeutic efficacy

Identifiers

PMID38539221
PMCPMC10976765
OpenAlexW4393216829

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.