Evidence map›Paper›PMID 38539204›Full record

SynthesisHead & face medicine2024

Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review.

Saeideh Ghasemi, Bardia Mortezagholi, Emad Movahed, Sahar Sanjarian, Arshin Ghaedi, Amirhossein Mallahi, Aida Bazrgar, Monireh Khanzadeh, Brandon Lucke-Wold, Shokoufeh Khanzadeh

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Head & face medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saeideh GhasemiDental school, Tabriz University of Medical Sciences, Tabriz, Iran.
Bardia MortezagholiDental Research Center, Faculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran.
Emad MovahedDental Research Center, Faculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran.
Sahar SanjarianIslamic Azad University of Medical Sciences, Tehran, Iran.
Arshin GhaediStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Amirhossein MallahiStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Aida BazrgarStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Monireh KhanzadehGeriatric & Gerontology Department, Medical School, Tehran University of medical and health sciences, Tehran, Iran.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, USA.
Shokoufeh KhanzadehTabriz University of Medical Sciences, Tabriz, Iran. khshokufe7@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe conducted this systematic review to compile the evidence for the role of neutrophil to lymphocyte ratio (NLR) in odontogenic infection (OI) and to determine whether NLR is elevated in patients with OI. This was done to aid physicians in better understanding this condition for clinical management.

methodsThe search was conducted on PubMed, Scopus, and Web of Science libraries on March 30, 2023. Two reviewers independently screened the studies using Endnote software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies.

resultsA total of nine studies were included in the review. Among patients with OI, positive and statistically significant correlations of NLR were seen with more severe disease, a prolonged hospital stay, postoperative requirement of antibiotics, and total antibiotic dose needed. In the receiver operating characteristics (ROC) analysis, the optimum cut-off level of NLR was 5.19 (specificity: 81, sensitivity: 51). In addition, NLR was correlated with preoperative fever (p = 0.001). Among patients with Ludwig's Angina, NLR could predict disease severity and length of stay in the hospital (p = 0.032 and p = 0.033, respectively). In addition, the relationship between the NLR and mortality was statistically significant (p = 0.026, specificity of 55.5%, and sensitivity of 70.8%). Among patients with severe oral and maxillofacial space infection, a positive correlation was found between IL-6 and CRP with NLR (rs = 0.773, P = 0.005 and rs = 0.556, P = 0.020, respectively). Also, a higher NLR was considered an essential predictor of organ involvement (P = 0.027) and the number of complications (P = 0.001). However, among diabetes mellitus (DM) patients afflicted with submandibular abscesses, NLR had no association with therapeutic response.

conclusionsMany people around the world suffer from OI, and a cheap and fast biomarker is needed for it. Interestingly, inflammation plays a role in this infection, and elevated NLR levels can be a good biomarker of inflammation and, as a result, for OI progression.

Indexed as

LymphocytesNeutrophilsBiomarkersHumansInflammationLymphocyte CountRetrospective StudiesBiomarkersInflammationNeutrophil to Lymphocyte RatioOdontogenic infectionSystematic review

Identifiers

PMID38539204
PMCPMC10976758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.