ArticleMicrobial cell factories2024
Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains.
Article in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Systems-level genomic and functional characterization of lipopeptide biosurfactant pathways in Bacillus albus MITWPUB5.World journal of microbiology & biotechnology · 2026Article
- Immunomodulatory Properties of the Cyclic Lipopeptide Surfactin.Journal of microbiology and biotechnology · 2026Review
- Surfactin Inhibits Osteoclast Differentiation by Negatively Regulating the Elk1-AP-1-NFATc1 Axis.Biomedicines · 2026Article
- Modulating Surfactin Biosynthesis in Bacillus subtilis R31 Enhances Behavioural Traits and Biocontrol Efficacy Against Banana Fusarium Wilt.Microbial biotechnology · 2025Article
- Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis.Microbial cell factories · 2025Article
- Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms.Microbial cell factories · 2025Article
- Transcriptomic and Biochemical Analysis of the Antimicrobial Mechanism of Lipopeptide Iturin W againstInternational journal of molecular sciences · 2024Article
- Effects of branched-chain amino acids on surfactin structure and antibacterial activity in Bacillus velezensis YA215.World journal of microbiology & biotechnology · 2024Article
- Investigation of the anti-Huanglongbing effects using antimicrobial lipopeptide and phytohormone complex powder prepared fromFrontiers in microbiology · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSurfactin, a green lipopeptide bio-surfactant, exhibits excellent surface, hemolytic, antibacterial, and emulsifying activities. However, a lack of clear understanding of the synthesis regulation mechanism of surfactin homologue components has hindered the customized production of surfactin products with different biological activities.
resultsIn this study, exogenous valine and 2-methylbutyric acid supplementation significantly facilitated the production of C14-C15 surfactin proportions (up to 75% or more), with a positive correlation between the homologue proportion and fortified concentration. Subsequently, the branched-chain amino acid degradation pathway and the glutamate synthesis pathway are identified as critical pathways in regulating C14-C15 surfactin synthesis by transcriptome analysis. Overexpression of genes bkdAB and glnA resulted in a 1.4-fold and 1.3-fold increase in C14 surfactin, respectively. Finally, the C14-rich surfactin was observed to significantly enhance emulsification activity, achieving an EI
conclusionThis study presents the first evidence of a potential connection between surfactin homologue synthesis and the conversion of glutamate and glutamine, providing a theoretical basis for targeting the synthesis regulation and structure-activity relationships of surfactin and other lipopeptide compounds.
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