ArticleBMC anesthesiology2024
Accelerated lymph flow from infusion of crystalloid fluid during general anesthesia.
Article in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Revisiting the fluid challenge and stroke volume optimisation after induction of general anaesthesia.Annals of intensive care · 2026Article
- Physiology and Molecular Mechanisms of the "Third Fluid Space".Journal of clinical medicine · 2025Review
- Where does the fluid go?Annals of intensive care · 2025Review
- Association of fluid management during robotic-assisted radical laparoscopic prostatectomy with early surgical clinical outcomes: a risk factor for lymphoceles.Journal of robotic surgery · 2025Article
- Attenuation of the plasma volume response to crystalloid fluid used for goal-directed fluid therapy.Annals of intensive care · 2025Article
- Capillary Filtration of Plasma Is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis.Journal of clinical pharmacology · 2025Article
- Open radical cystectomy and ileal loop diversion under combined spinal-epidural anaesthesia for the elderly and frail.BMC surgery · 2025Article
- Volume Kinetics of Gelofusine 4% During Vascular Surgery.Clinical pharmacokinetics · 2025Observational
- Sequential recruitment of body fluid spaces for increasing volumes of crystalloid fluid.Frontiers in physiology · 2024Article
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Authors and funding
1 author.
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Abstract
backgroundKinetic analysis of crystalloid fluid yields a central distribution volume (V
methodsA population volume kinetic analysis according to a three-compartment model was performed based on retrospective data from 160 infusion experiments during which 1-2.5 L of crystalloid fluid had been infused intravenously over 20-30 min. The plasma dilution based on blood hemoglobin (Hb) and plasma albumin (Alb) was measured on 2,408 occasions and the urine output on 454 occasions. One-third of the infusions were performed on anesthetized patients while two-thirds were given to awake healthy volunteers.
resultsThe Hb-Alb dilution difference was four times greater during general anesthesia than in the awake state (+ 0.024 ± 0.060 versus - 0.008 ± 0.050; mean ± SD; P < 0.001) which shows that more albumin entered the plasma than was lost by capillary leakage. The Hb-Alb dilution difference correlated strongly and positively with the kinetic parameters governing the rate of fluid transfer through the fast-exchange interstitial fluid compartment (k
conclusionsPronounced plasma volume expansion early during general anesthesia is associated with a positive intravascular albumin balance that is due to accelerated lymphatic flow. This phenomenon probably represents adjustment of the body fluid volumes to anesthesia-induced vasodilatation.
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