Evidence map›Paper›PMID 38539070›Full record

ArticleBMC bioinformatics2024

Slideflow: deep learning for digital histopathology with real-time whole-slide visualization.

James M Dolezal, Sara Kochanny, Emma Dyer, Siddhi Ramesh, Andrew Srisuwananukorn, Matteo Sacco, Frederick M Howard, Anran Li, Prajval Mohan, Alexander T Pearson

Abstract read
In one paragraph

Article in BMC bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James M DolezalSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA. james@slideflow.dev.
Sara KochannySection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Emma DyerSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Siddhi RameshSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Andrew SrisuwananukornDivision of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Matteo SaccoSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Frederick M HowardSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Anran LiSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Prajval MohanDepartment of Computer Science, University of Chicago, Chicago, IL, USA.
Alexander T PearsonSection of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA. alexander.pearson@bsd.uchicago.edu.

Funding

Multiscale Computational Models Guided By Emerging Cellular Dynamics Quantification For Predicting Optimum Immune Checkpoint And Targeted Therapy SchedulesU01CA243075 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, TRACHETTE · 2020 to 2024
$2.6M
NCI NIH HHS L30 CA264765NCI NIH HHS U01 CA243075NIH HHS K12-CA13916013NIH HHS U01-CA243075
6 · The paper itself

Abstract

Deep learning methods have emerged as powerful tools for analyzing histopathological images, but current methods are often specialized for specific domains and software environments, and few open-source options exist for deploying models in an interactive interface. Experimenting with different deep learning approaches typically requires switching software libraries and reprocessing data, reducing the feasibility and practicality of experimenting with new architectures. We developed a flexible deep learning library for histopathology called Slideflow, a package which supports a broad array of deep learning methods for digital pathology and includes a fast whole-slide interface for deploying trained models. Slideflow includes unique tools for whole-slide image data processing, efficient stain normalization and augmentation, weakly-supervised whole-slide classification, uncertainty quantification, feature generation, feature space analysis, and explainability. Whole-slide image processing is highly optimized, enabling whole-slide tile extraction at 40x magnification in 2.5 s per slide. The framework-agnostic data processing pipeline enables rapid experimentation with new methods built with either Tensorflow or PyTorch, and the graphical user interface supports real-time visualization of slides, predictions, heatmaps, and feature space characteristics on a variety of hardware devices, including ARM-based devices such as the Raspberry Pi.

Indexed as

Deep LearningComputersImage Processing, Computer-AssistedSoftwareComputational pathologyDigital pathologyExplainable AISelf-supervised learningSoftware toolkitWhole-slide imaging

Identifiers

PMID38539070
PMCPMC10967068

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.