Evidence map›Paper›PMID 38539051›Full record

ArticleImmunological medicine2024

High frequency of circulating non-classical monocytes is associated with stable remission in relapsing-remitting multiple sclerosis.

Misako Minote, Wakiro Sato, Kimitoshi Kimura, Atsuko Kimura, Youwei Lin, Tomoko Okamoto, Ryosuke Takahashi, Takashi Yamamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Misako MinoteDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0009-0006-5291-1377
Wakiro SatoDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0003-4082-3557
Kimitoshi KimuraDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0002-8359-2886
Atsuko KimuraDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0003-4244-637X
Youwei LinDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0001-7561-5577
Tomoko OkamotoMultiple Sclerosis Center, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0002-0983-3346
Ryosuke TakahashiDepartment of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-1407-9640
Takashi YamamuraDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID 0000-0001-9048-0375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

'No evidence of disease activity (NEDA)', judged by clinical and radiological findings, is a therapeutic goal in patients with multiple sclerosis (MS). It is, however, unclear if distinct biological mechanisms contribute to the maintenance of NEDA. To clarify the immunological background of long-term disease stability defined by NEDA, circulating immune cell subsets in patients with relapsing-remitting MS (RRMS) were analyzed using flow cytometry. Patients showing long-term NEDA (

Indexed as

MonocytesMultiple Sclerosis, Relapsing-RemittingT-Lymphocytes, RegulatoryAdultB7-H1 AntigenBiomarkersFemaleFlow CytometryHumansLymphocyte ActivationMaleMiddle AgedRemission InductionB7-H1 AntigenBiomarkersCD274 protein, humanactivated TregLong-term NEDAmultiple sclerosisnon-classical monocytePD-L1

Identifiers

PMID38539051
PMCPMC11346389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.