ArticleNature2024
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
Erratum issuedOpen access · greenAbstract read
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
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44citing papers in PubMed
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44 citing papers in PubMed, 51 citations in OpenAlex.
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- Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex.Nature communications · 2026Article
- Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature.World journal of gastrointestinal oncology · 2026Article
- DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SWI/SNF-associated molecular subtypes reshape tumor microenvironmental features and inform precision therapeutic strategies in bladder cancer.Frontiers in cellular and infection microbiology · 2026Article
- Chromatin Remodeling Subunit ARID1A Negatively Regulates the Malignant Progression of Gastrointestinal Stromal Tumors by Targeting the MEMO1 Promoter.International journal of medical sciences · 2026Article
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Corrections and comments
- Erratum issued
Authors and funding
26 authors at 5 institutions in 1 country.
Sandi Radko-Juettner *Division of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Hong Yue *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jacquelyn A MyersDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Raymond D CarterDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9226-9159
Alexis N RobertsonDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Priya MittalDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Zhexin ZhuDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Baranda S HansenDepartment of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2299-650X
Katherine A DonovanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-8539-5106
Moritz HunkelerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-0246-1188
Wojciech RosikiewiczCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7031-3430
Zhiping WuDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Meghan G McReynoldsDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7249-6314
Shourya S Roy BurmanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-9274-9104
Anna M SchmokerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nada MageedDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0009-0005-0046-6104
Scott A BrownDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Robert J MobleyDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Janet F PartridgeDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-1102-6305
Elizabeth A StewartDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-8005-0427
Shondra M Pruett-MillerDepartment of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3793-585X
Behnam NabetHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-6738-4200
Junmin PengDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0472-7648
Nathanael S GrayDepartment of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, Stanford Medicine, Stanford, CA, USA.ORCID 0000-0001-5354-7403
Eric S FischerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. eric_fischer@dfci.harvard.edu.ORCID 0000-0001-7337-6306
Charles W M RobertsDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA. charles.roberts@stjude.org.ORCID 0000-0003-1135-1896
St. Jude Children's Research Hospital · USHarvard University · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USStanford Medicine · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GERARD PAUL ZAMBETTI · 1985 to 2026
$166.9MTHE FUNCTION OF SNF5 (SMARCB1), AN EPIGENETIC TUMOR SUPPRESSORR01CA113794 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 2005 to 2026
$7.8MDissecting neuron-microglia-astrocyte interaction in AD pathogenesisRF1AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2020 to 2023
$5.4MRole of the SWI/SNF complex in tumor suppressionR01CA172152 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 2013 to 2026
$5.1MDevelopment of a generalizable chemo-proteomics screening platform for small molecule degraders applied to HDACsR01CA262188 · NCI · DANA-FARBER CANCER INST · PI FISCHER, ERIC SEBASTIAN · 2022 to 2025
$1.8MCancer-based discovery of novel mechanisms of chromatin controlR01CA273455 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 2023 to 2026
$1.6MTargeted disruption of the YAP/TAZ/TEAD axis in pancreatic cancerK22CA258805 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NABET, BEHNAM · 2021 to 2024
$644kMechanistic Studies of a Novel Vulnerability in Pediatric CancerF31CA261150 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC · PI RADKO-JUETTNER, SANDI · 2021 to 2022
$87kNCI NIH HHS F31 CA261150NCI NIH HHS K22 CA258805NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA113794NCI NIH HHS R01 CA172152NCI NIH HHS R01 CA262188NCI NIH HHS R01 CA273455NIA NIH HHS RF1 AG068581
Abstract
Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven by the inactivation of a subunit of SWI/SNF (also known as BAF) chromatin-remodelling complexes. Here, to generate mechanistic insights into the consequences of SMARCB1 mutation and to identify vulnerabilities, we contributed 14 SMARCB1-mutant cell lines to a near genome-wide CRISPR screen as part of the Cancer Dependency Map Project
Indexed as
Multiprotein ComplexesMutationNeoplasmsSMARCB1 ProteinAnimalsCell Line, TumorCRISPR-Cas SystemsFemaleGene EditingHumansMaleMiceProteolysisTumor Suppressor ProteinsUbiquitinMultiprotein ComplexesSMARCB1 ProteinSMARCB1 protein, humanTumor Suppressor ProteinsUbiquitin
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