ArticleNature2024
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
44.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Rethinking secondary immunodeficiency: a cross-domain pathway framework for risk stratification.Frontiers in immunology · 2026Pooled it
- Evaluating prognostic value of the prognostic nutritional index, CRP-to-albumin ratio and lymphocyte-to-CRP ratio in patients with idiopathic pulmonary fibrosis.Annals of medicine · 2026Article
- Immune pathways and prenatal/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration.Epigenetics · 2026Article
- Type 2 immunity as a counter-regulatory axis in aging.Nature aging · 2026Article
- Cytotoxic CD4Nature aging · 2026Article
- Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.Stem cell reviews and reports · 2026Review
- Multi-omic analysis of canine aging uncovers conserved aging pathways.GeroScience · 2026Article
- Lymph node contraction links sex-biased naive CD8Nature aging · 2026Article
- Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence.Signal transduction and targeted therapy · 2026Article
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.Nature aging · 2026Article
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- Age- and sex-dependent heterogeneity during LPS-induced murine acute lung injury.Immunity & ageing : I & A · 2026Article
- Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy.Nature communications · 2026Article
- Bile acids mediate liver-bone marrow crosstalk.iScience · 2026Article
- Multiome-based identification of molecular markers for prospective identification of platelet-biased HSCs.Stem cell reports · 2026Article
- Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging.Immunity · 2026Article
- Immune aging biomarkers for clinical trials.Nature medicine · 2026Review
- Improving lymphopoiesis in aged bone marrow.Current opinion in hematology · 2026Review
- Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.Aging cell · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 3 institutions in 2 countries.
Jason B Ross *Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0816-1314
Lara M Myers *Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Joseph J NohInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Madison M CollinsLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Aaron B CarmodyResearch Technologies Branch, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Ronald J MesserLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Erica DhueyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5961-0722
Kim J HasenkrugLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. khasenkrug@nih.gov.ORCID 0000-0001-8523-4911
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. irv@stanford.edu.ORCID 0000-0002-9077-7467
National Institutes of Health · USStanford University · USCalifornia Institute for Regenerative Medicine · US
Funding
Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8MMedical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0MStem Cell Biology, Cancer Stem Cell Biology, and Cancer ImmunotherapyR35CA220434 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2017 to 2023
$6.7MNRSA Training CoreTL1DK139565 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHILIP A BEACHY, Chi-yuan Hsu · 2023 to 2026
$5.1MProgrammed Cell Removal (PrCR) by Macrophages: recognition and phagocytosis of target cellsR01AI143889 · NIAID · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2020 to 2024
$2.0MTraining in Pediatric Nonmalignant Hematology and Stem Cell BiologyT32DK098132 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2014 to 2022
$1.9MCellular and molecular analyses of hematopoietic stem cell [HSC] interactions with bone marrow niches to improve HSC engraftment for transplantation and tolerance inductionR01DK115600 · NIDDK · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2018 to 2021
$1.5MNCI NIH HHS R35 CA220434NIAID NIH HHS R01 AI143889NIDDK NIH HHS R01 DK115600NIDDK NIH HHS T32 DK098132NIDDK NIH HHS TL1 DK139565NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM145402
Abstract
Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies
Indexed as
Adaptive ImmunityAgingCell LineageHematopoietic Stem CellsLymphocytesMyeloid CellsRejuvenationAnimalsB-LymphocytesFemaleInflammationLymphopoiesisMaleMiceMyelopoiesisPhenotype
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.