Evidence map›Paper›PMID 38538789›Full record

ArticleNature2024

Single-cell multiplex chromatin and RNA interactions in ageing human brain.

Xingzhao Wen, Zhifei Luo, Wenxin Zhao, Riccardo Calandrelli, Tri C Nguyen, Xueyi Wan, John Lalith Charles Richard, Sheng Zhong

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. LFPM inhibition of RING1-mediated p53Cell death and differentiation · 2026
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  6. Review
  7. The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026
    Review
  8. Article
  9. Review
  10. Microfluidic low-input profiling reveals lncRNA roles in disease.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Enhancer Dynamics for Gene Regulation in the Cardiovascular System.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xingzhao Wen *Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA.
Zhifei Luo *Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Wenxin ZhaoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Riccardo CalandrelliInstitute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
Tri C NguyenShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Xueyi WanShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
John Lalith Charles RichardInstitute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
Sheng ZhongProgram in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA, USA. szhong@ucsd.edu.ORCID 0000-0001-6419-7453
University of California San Diego · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI ALEXANDER, GENE E · 2001 to 2020
$32.5M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
The second phase of NIH Common Fund 4D Nucleome Network Organizational HubU01CA200147 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2015 to 2024
$22.0M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
Extremely high-throughput mapping of protein, RNA, and chromatin interactions in health and diseaseDP1DK126138 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2020 to 2024
$3.7M
Single Cell Tracking of 3D Epigenetic Landscape Evolution During Embryonic DevelopmentR01HD107206 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yingxiao Wang, Sheng Zhong · 2022 to 2026
$3.2M
Revealing protein-protein interactions and RNA-protein interactions at genome-scale in two weeksR01GM138852 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2020 to 2023
$1.5M
Spatial in situ mapping of RNA-chromatin interactions at transcriptome-and-genome scale in human tissuesUH3CA256960 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2022 to 2023
$1.1M
NCI NIH HHS U01 CA200147NCI NIH HHS UH3 CA256960NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NICHD NIH HHS R01 HD107206NIDDK NIH HHS DP1 DK126138NIGMS NIH HHS R01 GM138852NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

Dynamically organized chromatin complexes often involve multiplex chromatin interactions and sometimes chromatin-associated RNA

Indexed as

AgingCell NucleusChromatinFrontal LobeRNASingle-Cell AnalysisAgedAlzheimer DiseaseCellular SenescenceChromosomes, Human, XFemaleGene Expression ProfilingHumansMalePromoter Regions, GeneticQuantitative Trait LociChromatinRNARNA, Long NoncodingXIST non-coding RNA

Identifiers

PMID38538789
PMCPMC11023937
OpenAlexW4393219035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.