Evidence map›Paper›PMID 38538776›Full record

ArticleJournal of neurology2024

Brain microstructure is linked to cognitive fatigue in early multiple sclerosis.

Camille Guillemin, Nora Vandeleene, Maëlle Charonitis, Florence Requier, Gaël Delrue, Emilie Lommers, Pierre Maquet, Christophe Phillips, Fabienne Collette

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Camille Guillemin *GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Nora Vandeleene *GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Maëlle CharonitisGIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Florence RequierGIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Gaël DelrueDepartment of Neurology, CHU of Liège Sart Tilman, Liège, Belgium.
Emilie LommersGIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Pierre MaquetGIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Christophe Phillips *GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium.
Fabienne Collette *GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium. f.collette@uliege.be.ORCID http://orcid.org/0000-0001-9288-9756
University of Liège · BECentre Hospitalier Universitaire de Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive fatigue is a major symptom of Multiple Sclerosis (MS), from the early stages of the disease. This study aims to detect if brain microstructure is altered early in the disease course and is associated with cognitive fatigue in people with MS (pwMS) compared to matched healthy controls (HC). Recently diagnosed pwMS (N = 18, age < 45 years old) with either a Relapsing-Remitting or a Clinically Isolated Syndrome course of the disease, and HC (N = 19) matched for sex, age and education were analyzed. Quantitative multiparameter maps (MTsat, PD, R1 and R2*) of pwMS and HC were calculated. Parameters were extracted within the normal appearing white matter, cortical grey matter and deep grey matter (NAWM, NACGM and NADGM, respectively). Bayesian T-test for independent samples assessed between-group differences in brain microstructure while associations between score at a cognitive fatigue scale and each parameter in each tissue class were investigated with Generalized Linear Mixed Models. Patients exhibited lower MTsat and R1 values within NAWM and NACGM, and higher R1 values in NADGM compared to HC. Cognitive fatigue was associated with PD measured in every tissue class and to MTsat in NAWM, regardless of group. Disease-specific negative correlations were found in pwMS in NAWM (R1, R2*) and NACGM (R1). These findings suggest that brain microstructure within normal appearing tissues is already altered in the very early stages of the disease. Moreover, additional microstructure alterations (e.g. diffuse and widespread demyelination or axonal degeneration) in pwMS may lead to disease-specific complaint of cognitive fatigue.

Indexed as

BrainMagnetic Resonance ImagingMultiple SclerosisAdultCognitive DysfunctionFemaleGray MatterHumansMaleMental FatigueMiddle AgedMultiple Sclerosis, Relapsing-RemittingWhite MatterYoung AdultClinically isolated syndromeCognitive fatigueEarly multiple sclerosisFatigueQuantitative MRI

Identifiers

PMID38538776
OpenAlexW4393276193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.