Evidence map›Paper›PMID 38538775›Full record

ArticleJournal of neurology2024

Vestibular-evoked myogenic potential abnormalities in Parkinson's disease with freezing of gait.

Yuhan Jiang, Mengxi Zhou, Haibin Sheng, Shuai Xu, Yajing Chen, Li Wu, Qing He, Lei Zhao, Jianren Liu, Wei Chen

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuhan Jiang *Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengxi Zhou *Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haibin ShengDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuai XuDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yajing ChenDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li WuDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qing HeDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei ZhaoDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianren LiuDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei ChenDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. david_chen8106@hotmail.com.ORCID http://orcid.org/0000-0002-9003-1235
Shanghai Jiao Tong University · CN

Funding

200 talent project from Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 20161422Clinical research program of Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine JYLJ202003Fundamental research program funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine JYZZ209Health Management Project of Shanghai Rehabilitation Medical Association 2022KJCX008Natural Science Foundation Project from the Shanghai Municipal Science and Technology Commission 22ZR1436900Project of Biobank from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine YBKB202120Transverse Research Project of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYHX202117002
6 · The paper itself

Abstract

backgroundVestibular dysfunction is closely associated with the pathophysiology of Parkinson's disease (PD) accompanied by freezing of gait (FOG); however, evidence supporting this clinical association is lacking. Vestibular-evoked myogenic potentials (VEMPs) have been widely acknowledged as a crucial electrophysiological parameter in the clinical evaluation of vestibular function.

objectiveThe present study investigated the possible correlation of FOG occurrence with VEMP observations in patients diagnosed with PD.

methodsAltogether, 95 idiopathic PD patients were recruited into the present cross-sectional study. All patients underwent motor and non-motor assessments using serial scales. In addition, the electrophysiological vestibular evaluation was conducted, which included cervical (cVEMP) and ocular VEMP (oVEMP) assessments. Furthermore, the correlations of bilateral c/oVEMP absence with clinical phenotypes, especially FOG, among the PD patients were analyzed.

resultsAmong the 95 patients with PD, 44 (46.3%) had bilateral oVEMP absence and 23 (24.2%) had bilateral cVEMP absence, respectively. The proportions of patients with bilateral oVEMP absence (77.8% vs 30.9%, p = 0.004) and bilateral cVEMP absence (44.4% vs 19.5%, p = 0.035) were higher in the patient group exhibiting FOG than in the group without FOG. Following the adjustment of confounding variables, bilateral oVEMP absence (OR = 8.544, p = 0.007), rather than bilateral cVEMP absence, was shown to independently predict FOG occurrence in patients with PD.

conclusionThe close correlation between bilateral oVEMP absence and FOG in PD patients sheds new light on the possible role of central vestibular/upper brainstem dysfunction in FOG development in patients with PD.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseVestibular Evoked Myogenic PotentialsAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedVestibular DiseasesFreezing of gaitParkinson’s diseaseVestibular dysfunctionVestibular-evoked myogenic potential

Identifiers

PMID38538775
OpenAlexW4393234914

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.