Evidence map›Paper›PMID 38538585›Full record

ArticleScientific reports2024

Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children's Study (JECS).

Shiori Ishiyama, Kazuki Mochizuki, Ryoji Shinohara, Kunio Miyake, Megumi Kushima, Reiji Kojima, Sayaka Horiuchi, Sanae Otawa, Hideki Yui, Tadao Ooka and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 14 institutions in 1 country.

Shiori IshiyamaFaculty of Life and Environmental Sciences, University of Yamanashi, 4-4-37, Takeda, Kofu, Yamanashi, 400-8510, Japan.
Kazuki MochizukiFaculty of Life and Environmental Sciences, University of Yamanashi, 4-4-37, Takeda, Kofu, Yamanashi, 400-8510, Japan. mochizukik@yamanashi.ac.jp.
Ryoji ShinoharaCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Kunio MiyakeDepartment of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3821, Japan.
Megumi KushimaCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Reiji KojimaDepartment of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3821, Japan.
Sayaka HoriuchiCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Sanae OtawaCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Hideki YuiCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan.
Tadao OokaDepartment of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3821, Japan.
Yuka AkiyamaDepartment of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3821, Japan.
Hiroshi YokomichiDepartment of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3821, Japan.
Zentaro YamagataCenter for Birth Cohort Studies, University of Yamanashi, Chuo, Yamanashi, Japan. zenymgt@yamanashi.ac.jp.
Japan Environment and Children’s Study Group
University of Yamanashi Hospital · JPUniversity of Yamanashi · JPFukushima Medical University · JPKyoto University · JPKyushu University · JPNational Institute for Environmental Studies · JPTakeda (Japan) · JPTottori University Hospital · JPChiba University · JPHokkaido University · JPHyogo University · JPKumamoto University · JPNagoya City University · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) increase the risk of preterm births and cesarean delivery. This study aimed to investigate whether maternal blood leukocyte, monocyte, or neutrophil counts in the first trimester are related to the development of HDP. Data were collected from the Japan Environment and Children's Study, a large birth cohort study (n = 38,194) that recruited pregnant women in 15 Regional Centers across Japan (from January 2011 to March 2014). The odds ratios (ORs) for mild/severe HDP according to the cut-off value of leukocyte/neutrophil/monocyte counts by the receiver operating characteristic curve showed high ORs. Furthermore, pregnant women with the highest quartiles of leukocyte and monocyte counts had higher adjusted ORs (aORs) for mild (leukocyte: aOR = 1.27, 95% confidence interval [CI]: 1.02-1.58; monocyte: aOR = 1.30, 95% CI 1.04-1.63) and severe HDP (leukocyte: aOR = 1.51, 95% CI 1.08-2.13; monocyte: aOR = 1.44, 95% CI 1.03-2.01) compared with those with the lowest quartiles of those counts. In addition, pregnant women with the highest neutrophil counts had higher aOR for mild HDP (aOR = 1.26, 95% CI 1.02-1.56) compared with those with the lowest count. In conclusion, high leukocyte and monocyte counts in the first trimester are associated with the development of HDP. Thus, they may be used to predict subsequent HDP.

Indexed as

Hypertension, Pregnancy-InducedPre-EclampsiaChildCohort StudiesFemaleHumansInfant, NewbornJapanMonocytesNeutrophilsPregnancy

Identifiers

PMID38538585
PMCPMC10973522
OpenAlexW4393225402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.