ArticleNature communications2024
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Eusocial reproduction selects for longevity.bioRxiv : the preprint server for biology · 2026Article
- IGF-mediated glucose signalling is retained in adult naked mole-rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Resistance to age-related hypercoagulability: insights from the naked mole rat.Research and practice in thrombosis and haemostasis · 2026Article
- Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy.Nature cardiovascular research · 2026Article
- Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-RatMuscles (Basel, Switzerland) · 2026Article
- Hypoxic adaptation theory of cancer.Frontiers in cell and developmental biology · 2026Article
- Metabolomics-constrained modelling reveals dominant oxidative metabolism in the Egyptian fruit bat myocardium.PloS one · 2026Article
- Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice.Cells · 2025Article
- Impact of acute and chronic hypoxia on the heme oxygenase/carbon monoxide pathway in naked mole-rats (Heterocephalus glaber).The Journal of experimental biology · 2025Article
- Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes.Scientific reports · 2025Article
- Bat power-metabolic profiling of the Egyptian fruit batbioRxiv : the preprint server for biology · 2025Article
- Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.Nature cardiovascular research · 2025Article
- Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.bioRxiv : the preprint server for biology · 2025Article
- Lactate as a key energy source facilitating cooperative behaviour in helper Damaraland mole-rats.Biology letters · 2025Article
- Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype.Cardiovascular diabetology · 2025Article
- Article
- Evolutionary shifts in the thermal biology of a subterranean mammal: the effect of habitat aridity.The Journal of experimental biology · 2024Article
- Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.PLoS biology · 2024Article
- Four new genome sequences of the Pallas's cat (Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, metabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottentot golden mole and C57/BL6 mouse). We identify metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling glycolytic ATP generation during cardiac ischemia. Elevated normoxic expression of HIF-1α is observed while downstream hypoxia responsive-genes are down-regulated, suggesting adaptation to low oxygen environments. Naked mole-rat hearts show reduced succinate levels during ischemia compared to C57/BL6 mouse and negligible tissue damage following ischemia-reperfusion injury. These evolutionary traits reflect adaptation to a unique hypoxic and eusocial lifestyle that collectively may contribute to their longevity and health span.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.