Evidence map›Paper›PMID 38538285›Full record

ReviewFrontiers in bioscience (Landmark edition)2024

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium.

Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Hexokinase 2 promotes tumor development and progression.American journal of cancer research · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Erna MitaishviliDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Hanna FeinsodDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Zachary DavidDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Jessica ShpigelDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Chelsea FernandezDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Moira SauanePhD Program in Biology, The Graduate Center, City University of New York, New York, NY 10016, USA.
Columba de la ParraDepartment of Chemistry, Herbert H. Lehman College, City University of New York, New York, NY 10468, USA.
Lehman College · USThe Graduate Center, CUNY · US

Funding

U-RISE at Lehman CollegeT34GM149385 · NIGMS · HERBERT H. LEHMAN COLLEGE · PI Julio Gallego-Delgado, Donna McGregor · 2023 to 2026
$768k
Regulation of breast cancer cell metabolism by an alternate cap-dependent mechanism of translation initiation.SC2GM139676 · NIGMS · HERBERT H. LEHMAN COLLEGE · PI DE LA PARRA, COLUMBA · 2020 to 2022
$459k
NIGMS NIH HHS SC2 GM139676NIGMS NIH HHS T34 GM149385
6 · The paper itself

Abstract

Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in order to support their survival. This metabolic phenotype is referred to as the "Warburg effect" and is associated with an increase in glucose uptake, and a diversion of glycolytic intermediates to alternative pathways that support anabolic processes. These processes include synthesis of nucleic acids, lipids, and proteins, necessary for the rapidly dividing cancer cells, sustaining their growth, proliferation, and capacity for successful metastasis. Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with the poorest patient outcome due to its high rate of metastasis. TNBC is characterized by elevated glycolysis and in certain instances, low OXPHOS. This metabolic dysregulation is linked to chemotherapeutic resistance in TNBC research models and patient samples. There is more than a single mechanism by which this metabolic switch occurs and here, we review the current knowledge of relevant molecular mechanisms involved in advanced breast cancer metabolism, focusing on TNBC. These mechanisms include the Warburg effect, glycolytic adaptations, microRNA regulation, mitochondrial involvement, mitochondrial calcium signaling, and a more recent player in metabolic regulation, JAK/STAT signaling. In addition, we explore some of the drugs and compounds targeting cancer metabolic reprogramming. Research on these mechanisms is highly promising and could ultimately offer new opportunities for the development of innovative therapies to treat advanced breast cancer characterized by dysregulated metabolism.

Indexed as

Oxidative PhosphorylationTriple Negative Breast NeoplasmsCalciumCell Line, TumorGlycolysisHumansSignal TransductionCalciumglycolysishexokinaseJAK/STATmetabolic reprogrammingmiRNAsmitochondrial CaOXPHOSROSTNBCWarburg effect

Identifiers

PMID38538285
PMCPMC10999756
OpenAlexW4392924538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.