Evidence map›Paper›PMID 38538076›Full record

ArticleJournal of clinical pathology2025

Benchmarking digital displays (monitors) for histological diagnoses: the nephropathology use case.

Giorgio Cazzaniga, Francesco Mascadri, Stefano Marletta, Alessandro Caputo, Gabriele Guidi, Giovanni Gambaro, Albino Eccher, Angelo Paolo Dei Tos, Fabio Pagni, Vincenzo L'Imperio

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 citations in OpenAlex.

  1. Considerations for digital pathology displays.Journal of pathology informatics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Giorgio CazzanigaDepartment of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo dei Tintori, University of Milano-Bicocca, Monza, Italy.ORCID http://orcid.org/0000-0001-5373-0611
Francesco MascadriDepartment of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo dei Tintori, University of Milano-Bicocca, Monza, Italy.
Stefano MarlettaDivision of Pathology, Humanitas Cancer Center, Catania, Italy.ORCID http://orcid.org/0000-0001-7881-8767
Alessandro CaputoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", San Giovanni di Dio e Ruggi d'Aragona University Hospital, University of Salerno, Salerno, Italy.
Gabriele GuidiMedical Physics Unit, University Hospital of Modena, Modena, Italy.
Giovanni GambaroDivision of Nephrology, Department of Medicine, University of Verona, Verona, Italy.
Albino EccherDepartment of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy.
Angelo Paolo Dei TosSurgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
Fabio PagniDepartment of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo dei Tintori, University of Milano-Bicocca, Monza, Italy.ORCID http://orcid.org/0000-0001-9625-1637
Vincenzo L'ImperioDepartment of Medicine and Surgery, Pathology, IRCCS Fondazione San Gerardo dei Tintori, University of Milano-Bicocca, Monza, Italy vincenzo.limperio@gmail.com.ORCID http://orcid.org/0000-0002-9284-2998
University of Milano-Bicocca · ITUniversity of Modena and Reggio Emilia · ITHumanitas University · ITUniversity of Padua · ITUniversity of Salerno · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe digital transformation of the pathology laboratory is being continuously sustained by the introduction of innovative technologies promoting whole slide image (WSI)-based primary diagnosis. Here, we proposed a real-life benchmark of a pathology-dedicated medical monitor for the primary diagnosis of renal biopsies, evaluating the concordance between the 'traditional' microscope and commercial monitors using WSI from different scanners.

methodsThe College of American Pathologists WSI validation guidelines were used on 60 consecutive renal biopsies from three scanners (Aperio, 3DHISTECH and Hamamatsu) using pathology-dedicated medical grade (MG), professional grade (PG) and consumer-off-the-shelf (COTS) monitors, comparing results with the microscope diagnosis after a 2-week washout period.

resultsMG monitor was faster (1090 vs 1159 vs 1181 min, delta of 6-8%, p<0.01), with slightly better performances on the detection of concurrent diseases compared with COTS (κ=1 vs 0.96, 95% CI=0.87 to 1), but equal concordance to the commercial monitors on main diagnosis (κ

conclusionsThe digital transformation needs careful assessment of the hardware component to support a smart and safe diagnostic process. Choosing the display for WSI is critical in the process and requires adequate planning.

Indexed as

BenchmarkingImage Interpretation, Computer-AssistedKidneyKidney DiseasesMicroscopyPathology, ClinicalBiopsyFemaleHumansMaleMiddle AgedReproducibility of Resultsdigital pathologymedical monitornephropathologrenal pathologywhole slide imagesWSI validation

Identifiers

PMID38538076
PMCPMC12573376
OpenAlexW4393218725

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.