ArticleThe American journal of pathology2024
Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models.
Maryknoll P Linscott, Jerry R Ren, Shelley A Gestl, Edward J Gunther
Open access · bronzeAbstract read
In one paragraphArticle in The American journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
4 authors at 1 institution in 1 country.
Maryknoll P LinscottThe Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Jerry R RenThe Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Shelley A GestlThe Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Edward J GuntherThe Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address: ejg12@psu.edu.
Hershey (United States) · US
Funding
Medical Scientist Training ProgramT32GM149380 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERT LEVENSON · 2023 to 2026
$2.3MGenetic Analysis of Breast Cancer Progression in Mice Using Inducible TranspositionR01CA212584 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GUNTHER, EDWARD J · 2017 to 2021
$1.7MModeling breast cancer relapse prevention in miceR01CA152222 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GUNTHER, EDWARD J · 2010 to 2014
$1.5MEXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015428 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI EVARTS, C M · 2000 to 2000
$1.1MNCI NIH HHS R01 CA152222NCI NIH HHS R01 CA212584NCRR NIH HHS C06 RR015428NIGMS NIH HHS T32 GM149380
6 · The paper itselfAbstract
A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting that carcinogen-induced mutations generate long-lived premalignant clones. How subsequent events influence the progression of specific premalignant clones remains poorly understood. Herein, multistage mouse models of mammary carcinogenesis were generated by combining chemical carcinogen exposure [using 7,12-dimethylbenzanthracene (DMBA)] with transgenes that enable inducible expression of one of two clinically relevant mammary oncogenes: c-MYC (MYC) or PIK3CA
Indexed as
Disease ProgressionMammary Neoplasms, Experimental9,10-Dimethyl-1,2-benzanthraceneAnimalsClass I Phosphatidylinositol 3-KinasesDisease Models, AnimalFemaleMiceMice, TransgenicMutationOncogenesPrecancerous ConditionsProto-Oncogene Proteins c-myc9,10-Dimethyl-1,2-benzanthraceneClass I Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-myc
Identifiers
PMID38537934
PMCPMC11220927
OpenAlexW4393143170
What OpenQuestion holds
Textmetadata
Read underepoch 390