Evidence map›Paper›PMID 38537782›Full record

ArticleRespiratory medicine2024

Comparison of organ involvement clusters in Black and White American sarcoidosis patients from a prospectively collected patient registry.

Logan J Harper, Anoosha Tauquir, Shuaiqi Huang, Xiaofeng Wang, Jonas C Schupp, Robert Baughman, Daniel A Culver

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Logan J HarperDepartment of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: Harperl3@ccf.org.
Anoosha TauquirDepartment of Pulmonary, Critical Care, and Sleep Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Shuaiqi HuangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Xiaofeng WangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Jonas C SchuppMedizinische Hochschule Hannover, Hannover, Germany.
Robert BaughmanUniversity of Cincinnati, Cincinnati, OH, USA.
Daniel A CulverDepartment of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USMedical College of Wisconsin · USMedizinische Hochschule Hannover · DEUniversity of Cincinnati · US

Funding

Improving sarcoidosis patients’ care with a collaboratively developed, patient centered programK23MD017284 · NIMHD · CLEVELAND CLINIC LERNER COM-CWRU · PI LOGAN HARPER · 2022 to 2026
$797k
Stochastic Deep Learning for Electronic Health Records: Localizing Learning with Massive and Fragmented DataR01GM152717 · NIGMS · PURDUE UNIVERSITY · PI LIANG, FAMING, WANG, XIAOFENG · 2023 to 2025
$600k
NIGMS NIH HHS R01 GM152717NIMHD NIH HHS K23 MD017284
6 · The paper itself

Abstract

backgroundDue to the heterogeneity of sarcoidosis, there is a need to define clinical phenotypes to allow for tailoring of clinical care and identification of more homogenous populations to facilitate research.

methodsWe utilized data from a prospectively collected registry of sarcoidosis patients seen at a single quaternary referral center between January 2019 and February 2021. We used multiple correspondence analysis (MCA) and k-means clustering to investigate if the clusters previously identified in the GenPhenReSa study were reproducible in a US population. We also investigated if these clusters were stable when the population was stratified by race.

resultsWe replicated 3 of the 5 clusters seen in the GenPhenReSa study in our cohort. We likewise identified similar clusters between White and Black patients with sarcoidosis. Differences in organ manifestations associations between White and Black patients were seen primarily in relation to cardiac, neurologic, and ocular involvement.

conclusionsThe organ clusters of liver-spleen, isolated pulmonary, and musculoskeletal-skin were reproducible in a US cohort, and in both Black and White patients.

Indexed as

Black or African AmericanRegistriesSarcoidosisWhite PeopleAdultAgedCluster AnalysisFemaleHumansLiverMaleMiddle AgedProspective StudiesSkin DiseasesSpleenUnited StatesCluster analysisOrgan involvementSarcoidosis

Identifiers

PMID38537782
PMCPMC11840713
OpenAlexW4393203753

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.