Evidence map›Paper›PMID 38537641›Full record

ArticleNeuron2024

An implantable device for wireless monitoring of diverse physio-behavioral characteristics in freely behaving small animals and interacting groups.

Wei Ouyang, Keith J Kilner, Rachael M P Xavier, Yiming Liu, Yinsheng Lu, Sophia M Feller, Kayla M Pitts, Mingzheng Wu, Jokubas Ausra, Ian Jones and 14 more

Open access · greenAbstract read
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Wei OuyangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Keith J KilnerQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA.
Rachael M P XavierNeuroLux Inc., Northfield, IL 60093, USA.
Yiming LiuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Yinsheng LuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Sophia M FellerNeuroLux Inc., Northfield, IL 60093, USA.
Kayla M PittsDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA.
Mingzheng WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jokubas AusraNeuroLux Inc., Northfield, IL 60093, USA.
Ian JonesNeuroLux Inc., Northfield, IL 60093, USA.
Yunyun WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Haiwen LuanQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Jacob TruebQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Elizabeth M Higbee-DempseyDevelopmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.
Iwona StepienDevelopmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.
Nayereh Ghoreishi-HaackDevelopmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.
Chad R HaneyCenter for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA.
Hao LiDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
Yevgenia KozorovitskiyDepartment of Neurobiology, Northwestern University, Evanston, IL 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.
Mitra HeshmatiDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Anthony R BanksQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA.
Sam A GoldenDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA. Electronic address: sagolden@uw.edu.
Cameron H GoodQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA. Electronic address: cameron.good@northwestern.edu.
John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Chemistry, Northwestern University, Evanston, IL 60208, USA; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA. Electronic address: jrogers@northwestern.edu.
Northwestern University · USLux Research (United States) · USUniversity of Washington · USDartmouth College · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchronyU01NS131406 · NINDS · NORTHWESTERN UNIVERSITY · PI DONALDSON, ZOE REBECCA, KOZOROVITSKIY, YEVGENIA · 2023 to 2025
$4.2M
Integrative single-cell spatial transcriptomic, anatomical, and functional profiling of brain-wide ensembles engaged by opioid relapseR01DA059374 · NIDA · UNIVERSITY OF WASHINGTON · PI Sam Golden, Liangcai Gu · 2023 to 2026
$3.1M
Mechanisms of emergence from general anesthesiaR35GM146751 · NIGMS · UNIVERSITY OF WASHINGTON · PI Mitra Heshmati · 2022 to 2026
$2.3M
Understanding the role of paraventricular neurotensin neurons in valence processingR00DA055111 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hao Li · 2024 to 2026
$827k
Wireless Implantable Mechano-Acoustic Recording DeviceR43EB033239 · NIBIB · NEUROLUX, INC. · PI GOOD, CAMERON · 2022 to 2022
$260k
NCI NIH HHS P30 CA060553NIBIB NIH HHS R43 EB033239NIDA NIH HHS R00 DA055111NIDA NIH HHS R01 DA059374NIGMS NIH HHS L40 GM139224NIGMS NIH HHS R35 GM146751NINDS NIH HHS U01 NS131406
6 · The paper itself

Abstract

Comprehensive, continuous quantitative monitoring of intricately orchestrated physiological processes and behavioral states in living organisms can yield essential data for elucidating the function of neural circuits under healthy and diseased conditions, for defining the effects of potential drugs and treatments, and for tracking disease progression and recovery. Here, we report a wireless, battery-free implantable device and a set of associated algorithms that enable continuous, multiparametric physio-behavioral monitoring in freely behaving small animals and interacting groups. Through advanced analytics approaches applied to mechano-acoustic signals of diverse body processes, the device yields heart rate, respiratory rate, physical activity, temperature, and behavioral states. Demonstrations in pharmacological, locomotor, and acute and social stress tests and in optogenetic studies offer unique insights into the coordination of physio-behavioral characteristics associated with healthy and perturbed states. This technology has broad utility in neuroscience, physiology, behavior, and other areas that rely on studies of freely moving, small animal models.

Indexed as

Behavior, AnimalOptogeneticsWireless TechnologyAlgorithmsAnimalsHeart RateMaleMiceMonitoring, PhysiologicProstheses and ImplantsRespiratory Ratebehaviorimplantablemechano-acousticneural circuitsphysiologysignal processingwireless

Identifiers

PMID38537641
PMCPMC11256974
OpenAlexW4393190993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.