Evidence map›Paper›PMID 38537631›Full record

ArticleCell stem cell2024

Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment.

Adrian A Epstein, Sara N Janos, Luca Menozzi, Kelly Pegram, Vaibhav Jain, Logan C Bisset, Joseph T Davis, Samantha Morrison, Aswathy Shailaja, Yingqiu Guo and 17 more

Open access · greenAbstract read
In one paragraph

Article in Cell stem cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The Role of Chaf1b in Maintaining Glioma Stem Cell Stemness and Regulating Microglial Polarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 1 country.

Adrian A EpsteinDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Sara N JanosDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA.
Luca MenozziDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Kelly PegramDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Vaibhav JainDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Logan C BissetDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA.
Joseph T DavisDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA.
Samantha MorrisonDepartment of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Aswathy ShailajaDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Yingqiu GuoDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Agnes S ChaoDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Khadar AbdiDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Blaire RikardDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Simon G GregoryDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.
Kimberley FisherDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Rick PittmanDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Al ErkanliDepartment of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Kathryn E GustafsonDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Caroline W T CarricoDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA.
William F MalcolmDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Terrie E InderDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
C Michael CottenDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA.
Trevor D BurtDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA; Children's Health and Discovery Initiative, Duke University School of Medicine, Durham, NC, USA.
Mari L ShinoharaDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Charles M MaxfieldDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA. Electronic address: charles.maxfield@duke.edu.
Eric J BennerDepartment of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: eric.benner@duke.edu.
Duke University · USHarvard University · US

Funding

RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026
$6.1M
Unified Program for Therapeutics in Children (UPTiC)T32HD094671 · NICHD · DUKE UNIVERSITY · PI Ian J Davis, Kanecia Obie Zimmerman · 2019 to 2026
$2.9M
Mechanisms of oxysterol-induced oligodendrogenesisR01NS114578 · NINDS · DUKE UNIVERSITY · PI BENNER, ERIC J · 2020 to 2024
$2.8M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Protective role of Clec7a/dectin-1 in CNS autoimmunityR01NS120417 · NINDS · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI160737NIAID NIH HHS T32 AI007062NICHD NIH HHS T32 HD094671NINDS NIH HHS R01 NS114578NINDS NIH HHS R01 NS120417
6 · The paper itself

Abstract

Brain injury is highly associated with preterm birth. Complications of prematurity, including spontaneous or necrotizing enterocolitis (NEC)-associated intestinal perforations, are linked to lifelong neurologic impairment, yet the mechanisms are poorly understood. Early diagnosis of preterm brain injuries remains a significant challenge. Here, we identified subventricular zone echogenicity (SVE) on cranial ultrasound in preterm infants following intestinal perforations. The development of SVE was significantly associated with motor impairment at 2 years. SVE was replicated in a neonatal mouse model of intestinal perforation. Examination of the murine echogenic subventricular zone (SVZ) revealed NLRP3-inflammasome assembly in multiciliated FoxJ1

Indexed as

Brain InjuriesIntestinal PerforationMotor DisordersPremature BirthAnimalsFemaleHumansInfantInfant, NewbornInfant, PrematureLateral VentriclesMiceStem Cell Nichecerebral palsycranial ultrasoundependymalinflammasomeintestinal perforationnecrotizing enterocolitisneonatal brain injuryneural stem cellneurodevelopmental outcomenichepreterm infantsubventricular zonewhite matter injury

Identifiers

PMID38537631
PMCPMC11129818
OpenAlexW4393190892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.