Evidence map›Paper›PMID 38537414›Full record

ArticleMedical image analysis2024

Self-supervised learning for medical image analysis: Discriminative, restorative, or adversarial?

Fatemeh Haghighi, Mohammad Reza Hosseinzadeh Taher, Michael B Gotway, Jianming Liang

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Autodidactic dense anatomical models.Medical image analysis · 2026
    Article
  5. Article
  6. Vision Foundry: A System for Training Foundational Vision AI Models.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fatemeh HaghighiSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85281, USA.
Mohammad Reza Hosseinzadeh TaherSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85281, USA.
Michael B GotwayDepartment of Radiology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Jianming LiangSchool of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ 85281, USA. Electronic address: Jianming.Liang@asu.edu.
Arizona State University · USMayo Clinic in Arizona · US

Funding

Computer-Aided Diagnosis of Pulmonary EmbolismR01HL128785 · NHLBI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIANG, JIANMING · 2016 to 2019
$2.5M
NHLBI NIH HHS R01 HL128785
6 · The paper itself

Abstract

Discriminative, restorative, and adversarial learning have proven beneficial for self-supervised learning schemes in computer vision and medical imaging. Existing efforts, however, fail to capitalize on the potentially synergistic effects these methods may offer in a ternary setup, which, we envision can significantly benefit deep semantic representation learning. Towards this end, we developed DiRA, the first framework that unites discriminative, restorative, and adversarial learning in a unified manner to collaboratively glean complementary visual information from unlabeled medical images for fine-grained semantic representation learning. Our extensive experiments demonstrate that DiRA: (1) encourages collaborative learning among three learning ingredients, resulting in more generalizable representation across organs, diseases, and modalities; (2) outperforms fully supervised ImageNet models and increases robustness in small data regimes, reducing annotation cost across multiple medical imaging applications; (3) learns fine-grained semantic representation, facilitating accurate lesion localization with only image-level annotation; (4) improves reusability of low/mid-level features; and (5) enhances restorative self-supervised approaches, revealing that DiRA is a general framework for united representation learning. Code and pretrained models are available at https://github.com/JLiangLab/DiRA.

Indexed as

Hereditary Autoinflammatory DiseasesHumansInterleukin 1 Receptor Antagonist ProteinSemanticsSupervised Machine LearningInterleukin 1 Receptor Antagonist ProteinFine-grained representation learningSelf-supervised LearningTransfer Learning

Identifiers

PMID38537414
PMCPMC11044023
OpenAlexW4391292937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.