Evidence map›Paper›PMID 38537162›Full record

ArticleACS biomaterials science & engineering2024

Advancing Bone-Targeted Drug Delivery: Leveraging Biological Factors and Nanoparticle Designs to Improve Therapeutic Efficacy.

Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Baixue XiaoDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.ORCID 0000-0001-8337-8401
Marian A Ackun-FarmmerDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.
Emmanuela Adjei-SowahDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.
Yuxuan LiuMaterials Science Program, University of Rochester, Rochester, New York 14623, United States.
Indika ChandrasiriDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.
Danielle S W BenoitDepartment of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.ORCID 0000-0001-7137-8164
University of Rochester Medical Center · USUniversity of Oregon · USUniversity of Rochester · US

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
Engineering scarless repair of flexor tendon injuriesR01AR056696 · NIAMS · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A, BENOIT, DANIELLE S. · 2009 to 2019
$3.6M
Mechanisms that Regulate Skin Wound HealingR01AR069550 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2016 to 2020
$1.8M
Bone-targeted polymer therapeutics for nonunion fracture healingR21AG072692 · NIA · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S. · 2022 to 2023
$406k
Tendon TRAP: Targeted Therapeutic Delivery to Enhance Tendon HealingR21AR081063 · NIAMS · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., LOISELLE, ALAYNA · 2022 to 2023
$373k
Molecular Multispectral ImagingS10RR026542 · NCRR · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A · 2010 to 2010
$370k
Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF/TOF) Mass SpectrometerS10OD030302 · OD · UNIVERSITY OF ROCHESTER · PI NILSSON, BRADLEY L. · 2021 to 2021
$304k
Nanoparticle mediated microenvironmental targeting of CCL3 signaling for the treatment of acute myelogenous leukemiaF31CA228391 · NCI · UNIVERSITY OF ROCHESTER · PI ACKUN-FARMMER, MARIAN ADRIANA · 2018 to 2020
$94k
NCI NIH HHS F31 CA228391NCRR NIH HHS S10 RR026542NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056696NIAMS NIH HHS R01 AR064200NIAMS NIH HHS R01 AR069550NIAMS NIH HHS R21 AR081063NIA NIH HHS R21 AG072692NIH HHS S10 OD030302
6 · The paper itself

Abstract

Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene-

Indexed as

Drug Delivery SystemsNanoparticlesAnimalsLigandsMiceMice, Inbred C57BLPeptidesTissue DistributionLigandsPeptidesbiodistributionbone targetingligand densitynanoparticlestargeted drug delivery

Identifiers

PMID38537162
PMCPMC13539760
OpenAlexW4393214337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.