ArticleThe British journal of surgery2024
Impact of type 2 diabetes on complications after primary breast cancer surgery: Danish population-based cohort study.
Article in The British journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Metabolic syndrome is associated with breast cancer mortality: A systematic review and meta-analysis.Journal of internal medicine · 2025Pooled it
- The Role of Internal Medicine or Hospitalist Co-Management in Surgical Specialties: Implications for Adult and Elderly Plastic Surgery Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Construction and validation of a prognostic model for seroma after breast cancer surgery: a dual-center retrospective cohort study.Frontiers in oncology · 2026Article
- Postoperative Outcomes in Tumescent Local Anaesthesia for Reduction Mammaplasty and the Impact of Comorbidities.Aesthetic plastic surgery · 2025Article
- Complication Rates are Low After Invasive Procedures on the Lactating Breast in Patients Treated for Breast Cancer During Pregnancy.Annals of surgical oncology · 2025Article
- Impact of postoperative complications and type 2 diabetes on breast cancer recurrence and mortality.The British journal of surgery · 2025Article
- Pain and lymphedema characteristics of women with breast cancer-related lymphedema with and without type 2 diabetes mellitus.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Postoperative outcomes in patients with diabetes after enhanced recovery thoracoscopic lobectomy.Surgical endoscopy · 2024Article
- Correspondence to comment on: Impact of type 2 diabetes on complications after primary breast cancer surgery: Danish population-based cohort study.The British journal of surgery · 2024Article
- Comment on: Impact of type 2 diabetes on complications after primary breast cancer surgery: Danish population-based cohort study.The British journal of surgery · 2024Article
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6 authors at 2 institutions in 2 countries.
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Abstract
backgroundKnowledge is sparse on the impact of type 2 diabetes (T2D) on surgical outcomes after breast cancer surgery. This study investigated the association between T2D and risk of complications after primary breast cancer surgery, and evaluated the biological interaction between T2D and co-morbidities.
methodsUsing the Danish Breast Cancer Group clinical database, a cohort of all Danish women diagnosed with early-stage breast cancer during 1996-2022 was created. All patients underwent mastectomy or breast-conserving surgery. Information on prevalent T2D was collected from Danish medical and prescription registries. Surgical complications were defined as hospital diagnoses for medical or surgical complications developing within 30 days after primary breast cancer surgery. The 30-day cumulative incidence proportion of complications was calculated, and Cox regression was used to estimate HRs. Interaction contrasts were computed to determine the additive interaction between T2D and co-morbidities on the incidence rate of complications.
resultsAmong 98 589 women with breast cancer, 6332 (6.4%) had T2D at breast cancer surgery. Overall, 1038 (16.4%) and 9861 (10.7%) women with and without T2D developed surgical complications, yielding cumulative incidence proportions of 16 (95% c.i. 15 to 17) and 11 (10 to 11)% respectively, and a HR of 1.43 (95% c.i. 1.34 to 1.53). The incidence rate of surgical complications explained by the interaction of T2D with moderate and severe co-morbidity was 21 and 42%, respectively.
conclusionWomen with breast cancer and T2D had a higher risk of complications after primary breast cancer surgery than those without T2D. A synergistic effect of T2D and co-morbidity on surgical complications can explain this association.
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