ArticleScience advances2024
A different interpretation of the DIANA fMRI signal.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.Magnetic resonance in medicine · 2026Article
- Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Stimulus-induced rotary saturation imaging of visually evoked response: A pilot study.NMR in biomedicine · 2025Article
- Limitations of 2-dimensional line-scan MRI for directly measuring neural activity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Direct detection of neural activity by functional magnetic resonance imaging (fMRI) has been a longstanding goal in neuroscience. A recent study argued that it is possible to detect neuroelectrical potentials using a specialized fMRI scanning approach the authors termed "direct imaging of neuronal activity" (DIANA). We implemented DIANA in anesthetized rats and measured responses to somatosensory stimulation, reproducing core findings of the original study. We show, however, that neural activity is neither sufficient nor necessary to produce such results. We use a combination of control conditions and simulations to demonstrate that DIANA signals can arise from nonideal aspects of the pulse sequence and specimen that help determine spatiotemporal characteristics of the data. Our analysis emphasizes a need for cautious interpretation and mechanistic evaluation of advanced fMRI techniques.
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