ArticleScience advances2024
No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.Magnetic resonance in medicine · 2026Article
- Outlook on zero/ultrashort echo time techniques in functional MRI.Magnetic resonance in medicine · 2026Review
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- Stimulus-induced rotary saturation imaging of visually evoked response: A pilot study.NMR in biomedicine · 2025Article
- Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement.Research (Washington, D.C.) · 2025Review
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- This fMRI technique promised to transform brain research - why can no one replicate it?Nature · 2024Article
- No observation of DIANA signals in rats at 7.0 and 17.2 Tesla.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Alpha-180 spin-echo-based line-scanning method for high-resolution laminar-specific fMRI in animals.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Limitations of 2-dimensional line-scan MRI for directly measuring neural activity.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI.Frontiers in neuroimaging · 2024Article
- Initial experiences with Direct Imaging of Neuronal Activity (DIANA) in humans.Imaging neuroscience (Cambridge, Mass.) · 2023Article
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7 authors.
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Abstract
Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in anesthetized mice. The blood oxygenation level-dependent (BOLD) response to whisker stimulation was reliably detected in the primary barrel cortex before and after DIANA experiments; however, no DIANA-like fMRI peak was observed in individual animals' data with the 50 to 300 trials. Extensively averaged data involving 1050 trials in six mice showed a flat baseline and no detectable neuronal activity-like fMRI peak. However, spurious, nonreplicable peaks were found when using a small number of trials, and artifactual peaks were detected when some outlier-like trials were excluded. Further, no detectable DIANA peak was observed in the BOLD-responding thalamus from the selected trials with the neuronal activity-like reference function in the barrel cortex. Thus, we were unable to replicate the previously reported results without data preselection.
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