Evidence map›Paper›PMID 38536872›Full record

ArticleeLife2024

Membrane contact sites regulate vacuolar fission via sphingolipid metabolism.

Kazuki Hanaoka, Kensuke Nishikawa, Atsuko Ikeda, Philipp Schlarmann, Saku Sasaki, Sotaro Fujii, Sayumi Yamashita, Aya Nakaji, Kouichi Funato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kazuki Hanaoka *Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Kensuke Nishikawa *Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Atsuko Ikeda *Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.ORCID https://orcid.org/0000-0002-4710-5112
Philipp SchlarmannGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Saku SasakiGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Sotaro FujiiGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Sayumi YamashitaSchool of Applied Biological Science, Hiroshima University, Higashi-Hiroshima, Japan.
Aya NakajiSchool of Applied Biological Science, Hiroshima University, Higashi-Hiroshima, Japan.
Kouichi FunatoGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.ORCID https://orcid.org/0000-0002-1486-1296
Hiroshima University · JP

Funding

Japan Society for the Promotion of Science 19H02922Japan Society for the Promotion of Science 21K19088Japan Society for the Promotion of Science 21K20572Japan Society for the Promotion of Science 22K14863
6 · The paper itself

Abstract

Membrane contact sites (MCSs) are junctures that perform important roles including coordinating lipid metabolism. Previous studies have indicated that vacuolar fission/fusion processes are coupled with modifications in the membrane lipid composition. However, it has been still unclear whether MCS-mediated lipid metabolism controls the vacuolar morphology. Here, we report that deletion of tricalbins (Tcb1, Tcb2, and Tcb3), tethering proteins at endoplasmic reticulum (ER)-plasma membrane (PM) and ER-Golgi contact sites, alters fusion/fission dynamics and causes vacuolar fragmentation in the yeast

Indexed as

Mitochondrial MembranesSaccharomyces cerevisiae ProteinsCell MembraneLipid MetabolismSaccharomyces cerevisiaeSphingolipidsVacuolesSaccharomyces cerevisiae ProteinsSphingolipidscell biologymembrane contact sitesS. cerevisiaesphingolipidtricalbinvacuolar morphology

Identifiers

PMID38536872
PMCPMC10972560
OpenAlexW4385281681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.