Evidence map›Paper›PMID 38536601›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2024

In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.

Shintaro Hoshino, Eri Momma, Mai Koeda, Yoshimasa Hoshikawa, Tomohide Tanabe, Noriyuki Kawami, Yuichi Kitasako, Katsuhiko Iwakiri

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shintaro HoshinoDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Eri MommaDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Mai KoedaDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Yoshimasa HoshikawaDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Tomohide TanabeDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Noriyuki KawamiDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Yuichi KitasakoDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.
Katsuhiko IwakiriDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan. k-iwa@nms.ac.jp.ORCID 0000-0002-5558-6104

Funding

Kakenhi JP20K082973
6 · The paper itself

Abstract

backgroundThe salivary secretion in patients with mild reflux esophagitis (RE) and non-erosive reflux disease is significantly lower in females, but not in males. However, sex differences in salivary secretion in patients with severe RE remain unknown. Therefore, the present study investigated sex differences in saliva secretion in patients with severe RE.

methodsSubjects consisted of 23 male patients with severe RE, 24 male healthy controls (HCs), 26 female patients with severe RE, and 25 female HCs. Saliva secretion was assessed as follows: each patient chewed sugarless gum for 3 min prior to endoscopy, and the amount and pH of saliva secreted before and after acid loading as an index of the acid-buffering capacity were measured.

resultsIn males, no significant differences were observed in the amount of saliva secretion, salivary pH, or the acid-buffering capacity between severe RE patients and HCs. In females, the amount of saliva secretion (severe RE: 2.4 [1.8-4.1], HCs: 5.3 [3.4-7.5], p = 0.0017), salivary pH (severe RE: 7.0 [6.7-7.3], HCs: 7.2 [7.1-7.3], p = 0.0455), and the acid-buffering capacity (severe RE: 5.9 [5.3-6.2], HCs: 6.2 [6.1-6.5], p = 0.0024) were significantly lower in severe RE patients than in HCs.

conclusionAmong females, the salivary secretion was significantly lower in severe RE patients than in HCs. This reduction in salivary secretion may contribute to the pathophysiology of severe RE in females.

Indexed as

Esophagitis, PepticSalivaAdultAgedCase-Control StudiesFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedSalivationSeverity of Illness IndexSex FactorsSaliva secretionSevere reflux esophagitisSex difference

Identifiers

PMID38536601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.