Evidence map›Paper›PMID 38535999›Full record

ArticleAging2024

M1 intestinal macrophages-derived exosomes promote colitis progression and mucosal barrier injury.

Rui Du, Sihan Chen, Chenyang Han, Zhongmei He, Hongyan Pei, Yang Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Sihan ChenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Chenyang HanDepartment of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
Zhongmei HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Hongyan PeiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Yang YangDepartment of Cardiology, Shenyang Medical College Affiliated Second Hospital, Shenyang 314005, China.
Jilin Agricultural University · CNJiaxing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis work aimed to investigate the role of M1 intestinal macrophages-derived exosomes (M1-Exo) in colitis and its mechanism.

methodsM1 polarization of intestinal macrophages was induced

resultsM1-exo aggravated the colitis and tissue inflammation in mice, activated the TLR4 signal, and destroyed the mucosal barrier. But M0 macrophages-derived exosomes (M0-Exo) did not have the above effects. Resatorvid treatment antagonized the roles of M1-exo. Moreover, as confirmed by cellular experiments

conclusionM1-exo serve as the pro-inflammatory mediator, which can promote mouse colitis progression by activating TLR4 signal.

Indexed as

ColitisExosomesSulfonamidesAnimalsMacrophagesMiceToll-Like Receptor 4ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateSulfonamidesToll-Like Receptor 4colitisexosomesinflammationM1 macrophages

Identifiers

PMID38535999
PMCPMC11006457
OpenAlexW4393180561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.