Evidence map›Paper›PMID 38535998›Full record

ArticleAging2024

Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.

Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Sher Bahadur PoudelDepartment of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
Dorra Frikha-BenayedDepartment of Biomedical Engineering, City College of New York, New York, NY 10031, USA.
Ryan R RuffDepartment of Epidemiology and Health Promotion, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
Gozde YildirimDepartment of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
Manisha DixitDepartment of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
Ron KorstanjeJackson Aging Center, Nathan Shock Center for Excellence in the Basic Biology of Aging, The Jackson’s Laboratories, Aging Center, Bar Harbor, ME 04609, USA.
Laura RobinsonJackson Aging Center, Nathan Shock Center for Excellence in the Basic Biology of Aging, The Jackson’s Laboratories, Aging Center, Bar Harbor, ME 04609, USA.
Richard A MillerDepartment of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA.
David E HarrisonThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
John R StrongGeriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
Mitchell B SchafflerDepartment of Biomedical Engineering, City College of New York, New York, NY 10031, USA.
Shoshana YakarDepartment of Molecular Pathobiology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA.
New York University · USJackson Laboratory · USCity College of New York · USThe University of Texas Health Science Center at San Antonio · USUniversity of Michigan · USYork University · US

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Interventions That Retard Mammalian AgingU01AG022308 · NIA · JACKSON LABORATORY · PI Ronny Korstanje · 2003 to 2026
$30.5M
Laboratory for Anti-Geric Testing, Evaluation and ResearchU01AG022303 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARD A MILLER · 2003 to 2026
$25.4M
Translational CoreP30AG038070 · NIA · JACKSON LABORATORY · PI Gary A Churchill · 2010 to 2026
$19.3M
Research Center in Minority Institutions (RCMI) at City CollegeU54MD017979 · NIMHD · CITY COLLEGE OF NEW YORK · PI M. Felice Marina GHILARDI · 2024 to 2026
$15.9M
Osteocyte Integrity and Bone RemodelingR01AR041210 · NIAMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHAFFLER, MITCHELL B · 1997 to 2019
$5.8M
Structural, Molecular and Functional Specialization in Osteocyte MechanosensingR01AR070547 · NIAMS · CITY COLLEGE OF NEW YORK · PI SCHAFFLER, MITCHELL B, SPRAY, DAVID C · 2018 to 2022
$3.2M
Diverse effects of somatopause and aging on the skeletonR01AG056397 · NIA · NEW YORK UNIVERSITY · PI SCHAFFLER, MITCHELL B, YAKAR, SHOSHANA · 2018 to 2022
$2.4M
Skyscan 1172 Ex-vivo MicroComputed Tomography SystemS10OD010751 · OD · NEW YORK UNIVERSITY · PI PARTRIDGE, NICOLA C · 2013 to 2013
$326k
Seahorse XFe24 Extracellular Flux AnalyzerS10OD026699 · OD · NEW YORK UNIVERSITY · PI YAKAR, SHOSHANA · 2020 to 2020
$177k
NIAMS NIH HHS R01 AR041210NIAMS NIH HHS R01 AR070547NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG038070NIA NIH HHS R01 AG056397NIA NIH HHS U01 AG022303NIA NIH HHS U01 AG022308NIH HHS S10 OD010751NIH HHS S10 OD026699NIMHD NIH HHS U54 MD017979
6 · The paper itself

Abstract

Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both

Indexed as

AntioxidantsMitochondrial DiseasesOrganophosphorus CompoundsAgingAnimalsFemaleMaleMethylene BlueMiceMice, Inbred C57BLOxidative StressUbiquinoneAntioxidantsMethylene BluemitoquinoneOrganophosphorus CompoundsUbiquinoneantioxidantsbonemethylene bluemicro-CTmitoquinone

Identifiers

PMID38535998
PMCPMC11006499
OpenAlexW4394019346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.