Evidence map›Paper›PMID 38535779›Full record

ArticleToxins2024

Screening TLR4 Binding Peptide from

Runhan Li, Yezhong Tang, Zening Chen, Yang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Ultra-short cyclic peptide CyZoological research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Runhan LiKey Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Guangxi Normal University, Ministry of Education, Guilin 541006, China.
Yezhong TangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Zening ChenKey Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Guangxi Normal University, Ministry of Education, Guilin 541006, China.ORCID 0000-0002-2266-7776
Yang LiuChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.ORCID 0000-0003-1725-8721
Chinese Academy of Sciences · CNGuangxi Normal University · CN

Funding

National Natural Science Foundation of China 31970423National Natural Science Foundation of China 32071242National Natural Science Foundation of China 32200379Natural Science Foundation of Sichuan Province 2022NSFSC0579
6 · The paper itself

Abstract

Toll-like receptor 4 (TLR4) is a crucial inflammatory signaling pathway that can serve as a potential treatment target for various disorders. A number of inhibitors have been developed for the TLR4 pathway, and although no inhibitors have been approved for clinical use, most have been screened against the TLR4-MD2 conformation. The venom gland is the organ of venomous snakes that secretes substances that are toxic to other animals. The level of gene transcription in venom glands is different from that in other tissues, includes a large number of biologically active ingredients, and is an important natural resource for the development of new drugs. We constructed a T7 phage display library using the cobra (

Indexed as

BacteriophagesNaja najaAnimalsMolecular Docking SimulationPeptidesToll-Like Receptor 4PeptidesToll-Like Receptor 4Naja atraphage displaysnake venom glandsurface plasmon resonance (SPR)TLR4

Identifiers

PMID38535779
PMCPMC10976260
OpenAlexW4392159473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.