Evidence map›Paper›PMID 38535607›Full record

ArticlePathogens (Basel, Switzerland)2024

Metagenomic Detection and Genetic Characterization of Human Sapoviruses among Children with Acute Flaccid Paralysis in Nigeria.

Uwem Etop George, Temitope O C Faleye, Lander De Coninck, Sheriff Tunde Agbaje, Ijeoma Maryjoy Ifeorah, Bernard Anyebe Onoja, Elijah Igbekele Oni, Adebowale Oluseyi Olayinka, Toluwani Goodnews Ajileye, Arthur Obinna Oragwa and 10 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Uwem Etop GeorgeAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede 232101, Nigeria.ORCID 0000-0001-5474-1048
Temitope O C FaleyeCenter for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Lander De ConinckLaboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-6847-2379
Sheriff Tunde AgbajeDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.ORCID 0000-0002-4775-9001
Ijeoma Maryjoy IfeorahDepartment of Medical Laboratory Science, Faculty of Health Science and Technology, College of Medicine, University of Nigeria Enugu Campus, Enugu 400241, Nigeria.ORCID 0000-0003-0911-7179
Bernard Anyebe OnojaDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.ORCID 0000-0001-5502-3224
Elijah Igbekele OniDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.
Adebowale Oluseyi OlayinkaDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.
Toluwani Goodnews AjileyeDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.
Arthur Obinna OragwaDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Jos, Jos 930003, Nigeria.ORCID 0000-0002-4873-2089
Toluwanimi Emmanuel AkinleyePhytomedicine Unit, Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan 200005, Nigeria.ORCID 0000-0002-7202-8112
Bolutife Olubukola PopoolaDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.ORCID 0009-0004-5868-7412
Oluwadamilola Gideon OsasonaDepartment of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, Redeemer's University, Ede 232101, Nigeria.ORCID 0000-0003-4887-9336
Olaitan Titilola OlayinkaNational Polio Laboratory, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.
Oluwadamilola Adefunke GeorgeNational Veterinary Research Institute, Vom 930101, Nigeria.
Ahmed Iluoreh MuhammadDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.ORCID 0000-0002-7679-5052
Isaac KomolafeDepartment of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede 232101, Nigeria.
Adekunle Johnson AdenijiDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.
Jelle MatthijnssensLaboratory of Viral Metagenomics, Department of Microbiology, Immunology and Transplantation, Rega Institute, Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-1188-9733
Moses Olubusuyi AdewumiDepartment of Virology, College of Medicine, University of Ibadan, Ibadan 200212, Nigeria.ORCID 0000-0002-5172-5808
University of Ibadan · NGRedeemer's University · NGRega Institute for Medical Research · BECenter for Environmental Health · USNational Veterinary Research Institute · NGUniversity of Jos · NGUniversity of Nigeria · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a metagenomic sequencing approach on stool samples from children with Acute Flaccid Paralysis (AFP), we describe the genetic diversity of Sapoviruses (SaVs) in children in Nigeria. We identified six complete genome sequences and two partial genome sequences. Several SaV genogroups and genotypes were detected, including GII (GII.4 and GII.8), GIV (GIV.1), and GI (GI.2 and GI.7). To our knowledge, this is the first description of SaV infections and complete genomes from Nigeria. Pairwise identity and phylogenetic analysis showed that the Nigerian SaVs were related to previously documented gastroenteritis outbreaks with associated strains from China and Japan. Minor variations in the functional motifs of the nonstructural proteins NS3 and NS5 were seen in the Nigerian strains. To adequately understand the effect of such amino acid changes, a better understanding of the biological function of these proteins is vital. The identification of distinct SaVs reinforces the need for robust surveillance in acute gastroenteritis (AGE) and non-AGE cohorts to better understand SaVs genotype diversity, evolution, and its role in disease burden in Nigeria. Future studies in different populations are, therefore, recommended.

Indexed as

Caliciviridae InfectionsFecesGenome, ViralGenotypeMetagenomicsPhylogenySapovirusChildChild, PreschoolFemaleGastroenteritisGenetic VariationHumansInfantMaleNigeriaAcute Flaccid ParalysisAcute GastroenteritismetagenomicsNigeriasapovirus

Identifiers

PMID38535607
PMCPMC10976229
OpenAlexW4393004486

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.