Evidence map›Paper›PMID 38535514›Full record

ReviewPediatric reports2024

Pediatric Lemierre's Syndrome: A Comprehensive Literature Review.

Salvatore Lavalle, Edoardo Masiello, Salvatore Cocuzza, Piero Pavone, Alessandra Di Nora, Christian Calvo-Henriquez, Jerome Rene Lechien, Miguel Mayo Yanez, Andrea Praticò, Manuela Ceccarelli and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Pediatric reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Salvatore LavalleFaculty of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.
Edoardo MasielloRadiology Unit, Department Clinical and Experimental, Experimental Imaging Center, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Salvatore CocuzzaDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" ENT Section, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6135-0958
Piero PavoneDepartment of Child and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, 95100 Catania, Italy.ORCID 0000-0002-5600-9560
Alessandra Di NoraDepartment of Child and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, 95100 Catania, Italy.ORCID 0000-0002-8960-4016
Christian Calvo-HenriquezService of Otolaryngology, Hospital Complex of Santiago de Compostela, 15701 Santiago de Compostela, Spain.ORCID 0000-0003-3580-0967
Jerome Rene LechienHead and Neck Study Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75000 Paris, France.ORCID 0000-0002-0845-0845
Miguel Mayo YanezHead and Neck Study Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75000 Paris, France.ORCID 0000-0002-1829-6597
Andrea PraticòFaculty of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.
Manuela CeccarelliFaculty of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.ORCID 0000-0001-5987-3576
Giannicola IannellaDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185 Rome, Italy.ORCID 0000-0003-1781-2809
Annalisa PaceDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185 Rome, Italy.
Federica Maria ParisiDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" ENT Section, University of Catania, 95123 Catania, Italy.ORCID 0009-0003-0998-726X
Giuseppe MagliuloDepartment of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185 Rome, Italy.ORCID 0000-0003-3052-1969
Antonino ManiaciFaculty of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.ORCID 0000-0002-1251-0185
Università degli Studi di Enna Kore · ITUniversity of Catania · ITSapienza University of Rome · ITComplexo Hospitalario Universitario A Coruña · ESUniversity of Mons · BEVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLemierre syndrome is a rare, potentially fatal complication of oropharyngeal infections characterized by septic thrombophlebitis of the internal jugular vein. It primarily affects healthy adolescents and young adults. Its incidence declined after the antibiotic era, but it may have resurged in recent decades, likely due to judicious antibiotic use and increasing bacterial resistance. Prompt diagnosis and treatment are imperative to prevent significant morbidity and mortality.

methodsLemierre syndrome has been called "the forgotten disease," with a reported incidence of around 3.6 cases per million. The mean age at presentation is around 20 years old, though it can occur at any age. Lemierre Syndrome follows an oropharyngeal infection, most commonly pharyngitis, leading to septic thrombophlebitis of the internal jugular vein.

conclusionsLemierre syndrome should be suspected in patients with prolonged pharyngitis followed by unilateral neck swelling and fevers. Early diagnosis and prompt antibiotic therapy are key, given the potential for disastrous outcomes if untreated. An increased awareness of Lemierre syndrome facilitates its timely management.

Indexed as

internal jugular vein thrombophlebitisLemierre’s syndromeneck abscesspediatricseptic thrombophlebitis

Identifiers

PMID38535514
PMCPMC10974575
OpenAlexW4392911018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.