Evidence map›Paper›PMID 38535505›Full record

ArticleProteomes2024

Quantitative Proteomics Reveal Region-Specific Alterations in Neuroserpin-Deficient Mouse Brain and Retina: Insights into Serpini1 Function.

Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa, Roshana Vander Wall, Dana Pascovici, Angela Godinez, Giovanna Galliciotti, Joao A Paulo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Shahab MirshahvaladiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0002-9145-6155
Nitin ChitranshiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Ardeshir AmirkhaniAustralian Proteome Analysis Facility, Macquarie University, Sydney, NSW 2109, Australia.
Rashi RajputMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Devaraj BasavarajappaMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Roshana Vander WallMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Dana PascoviciAustralian Proteome Analysis Facility, Macquarie University, Sydney, NSW 2109, Australia.
Angela GodinezMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Giovanna GalliciottiInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Joao A PauloDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4291-413X
Veer GuptaSchool of Medicine, Deakin University, Geelong, VIC 3125, Australia.
Stuart L GrahamMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Vivek GuptaMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0002-0202-7843
Mehdi MirzaeiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Macquarie University · AUAGRF Ltd · AUDeakin University · AUHarvard University · USUniversität Hamburg · DE

Funding

Australian Government's National Collaborative Research Infrastructure Scheme NA
6 · The paper itself

Abstract

Neural regeneration and neuroprotection represent strategies for future management of neurodegenerative disorders such as Alzheimer's disease (AD) or glaucoma. However, the complex molecular mechanisms that are involved in neuroprotection are not clearly understood. A promising candidate that maintains neuroprotective signaling networks is neuroserpin (Serpini1), a serine protease inhibitor expressed in neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury. Abnormal function of this protein has been implicated in several conditions including stroke, glaucoma, AD, and familial encephalopathy with neuroserpin inclusion bodies (FENIB). Here, we explore the potential biochemical roles of Serpini1 by comparing proteome changes between neuroserpin-deficient (NS

Indexed as

neurodegenerationneuroprotectionneuroserpinquantitative proteomicstandem mass tags

Identifiers

PMID38535505
PMCPMC10975625
OpenAlexW4392817720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.