Evidence map›Paper›PMID 38535458›Full record

ArticleMarine drugs2024

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from

Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J Hone, David Morgenstern, Victor M Chua, Iris Bea L Ramiro, Julita S Imperial, Lee S Leavitt and 10 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 3 countries.

Jorge L B NevesInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR-LA), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.ORCID 0000-0002-8398-8004
Cristoval UrcinoSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9437-7540
Kevin ChaseSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9968-1437
Cheryl DowellSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Arik J HoneSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9912-0955
David MorgensternDepartments of Biochemistry and Molecular Pharmacology, New York University Langone Medical Center, New York, NY 10016, USA.
Victor M ChuaSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0009-0001-9233-2592
Iris Bea L RamiroSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3971-3107
Julita S ImperialSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Lee S LeavittSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Jasmine PhanSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Fernando A FisherSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Maren WatkinsSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4127-1961
Shrinivasan RaghuramanSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-5625-4454
Jortan O TunSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-9635-2419
Beatrix M UeberheideDepartments of Biochemistry and Molecular Pharmacology, New York University Langone Medical Center, New York, NY 10016, USA.
J Michael McIntoshSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-9939-7981
Vitor VasconcelosInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR-LA), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.ORCID 0000-0003-3585-2417
Baldomero M OliveraSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-4556-1410
Joanna GajewiakSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3608-9935
University of Utah · USNYU Langone Health · USUniversidade do Porto · PTUniversity of the Philippines System · PH

Funding

“Conus venom peptides and their molecular targets: Using pharmaconomics and neuroethology as a framework for discovery”R01GM144719 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M, RAGHURAMAN, SHRINIVASAN · 2022 to 2025
$2.5M
Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical ResearchR35GM136430 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2020 to 2024
$2.3M
Life history-guided drug discovery from venomous marine snailsR01GM122869 · NIGMS · UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M, YANDELL, MARK DOUGLAS · 2018 to 2022
$1.5M
NIGMS NIH HHS GM136430, GM122869, GM48677, GM144719NIGMS NIH HHS R01 GM122869NIGMS NIH HHS R01 GM144719NIGMS NIH HHS R35 GM136430
6 · The paper itself

Abstract

The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs. Here, we describe the discovery and characterization of a novel conotoxin from

Indexed as

ConotoxinsConus SnailReceptors, Nicotinicalpha7 Nicotinic Acetylcholine ReceptorAmino Acid SequenceAnimalsCalciumMicealpha7 Nicotinic Acetylcholine ReceptorCalciumConotoxinsReceptors, NicotinicconotoxinConstellation PharmacologyDRG neuronsnAChRs

Identifiers

PMID38535458
PMCPMC10971446
OpenAlexW4392385116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.