Evidence map›Paper›PMID 38535439›Full record

ArticleMarine drugs2024

Algae-Based Nanoparticles for Oral Drug Delivery Systems.

Eliyahu Drori, Dhaval Patel, Sarah Coopersmith, Valeria Rahamim, Chen Drori, Suchita Suryakant Jadhav, Roni Avital, Yaakov Anker, Aharon Azagury

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  7. The Selective in vitro Cytotoxicity ofInternational journal of nanomedicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eliyahu DroriDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Dhaval PatelDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.ORCID 0000-0001-8388-5438
Sarah CoopersmithDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Valeria RahamimDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Chen DroriDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Suchita Suryakant JadhavDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.ORCID 0000-0002-6565-8335
Roni AvitalDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Yaakov AnkerDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.ORCID 0000-0003-4747-0774
Aharon AzaguryDepartment of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.ORCID 0000-0002-5819-4106
Ariel University · IL

Funding

Israeli Ministry of Innovation, Science, and Technology 0004492
6 · The paper itself

Abstract

Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage as oral DDSs by measuring their size, surface charge, morphology, encapsulation efficiency, mucoadhesion force, and cellular uptake into Caco-2 cells. The NPs composed of algal materials (aNPs) exhibited a spherical morphology with a size range of 126-606 nm and a surface charge of -9 to -38 mV. The mucoadhesive forces tested ex vivo against mice, pigs, and sheep intestines revealed significant variation between algae and animal models. Notably,

Indexed as

BiomimeticsNanoparticlesAnimalsBiological TransportCaco-2 CellsDrug Delivery SystemsHumansMiceSheepSwinealgaebioadhesionbiomimicrycellular uptakemucoadhesionnanoparticlesoral drug delivery

Identifiers

PMID38535439
PMCPMC10971847
OpenAlexW4392017677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.