Evidence map›Paper›PMID 38535328›Full record

ArticleMetabolites2024

Application of Clinical Blood Metabogram to Type 2 Diabetes Mellitus.

Petr G Lokhov, Elena E Balashova, Oxana P Trifonova, Dmitry L Maslov, Ekaterina A Shestakova, Marina V Shestakova, Ivan I Dedov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Petr G LokhovInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.ORCID 0000-0002-0730-1725
Elena E BalashovaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.ORCID 0000-0002-5314-5727
Oxana P TrifonovaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.ORCID 0000-0002-5803-2529
Dmitry L MaslovInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.ORCID 0000-0003-3003-7595
Ekaterina A ShestakovaEndocrinology Research Centre, 11 Dm. Ulianova Street, 117292 Moscow, Russia.ORCID 0000-0001-6612-6851
Marina V ShestakovaEndocrinology Research Centre, 11 Dm. Ulianova Street, 117292 Moscow, Russia.ORCID 0000-0002-5057-127X
Ivan I DedovEndocrinology Research Centre, 11 Dm. Ulianova Street, 117292 Moscow, Russia.
Institute of Biomedical Chemistry · RUEndocrinology Research Center · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2022-310Russian Foundation for Basic Research 122030100168-2
6 · The paper itself

Abstract

The clinical blood metabogram (CBM) was developed to match a tailored analysis of the blood metabolome to the time, cost, and reproducibility constraints of clinical laboratory testing. By analyzing the main blood metabolite groups, CBM offers clinically relevant information about the intake of low-molecular substances into the organism, humoral regulation, liver function, amino acid level, and the lipid and carbohydrate metabolism. The purpose of this work was to investigate the relevance of using the CBM in patients with diabetes mellitus. For this, a CBM was obtained for 18 healthy individuals, 12 individuals with prediabetes, and 64 individuals with type 2 diabetes mellitus, separated into groups according to fasting blood glucose and oral glucose tolerance tests. The results showed that the CBM reveals diabetes-associated metabolic alterations in the blood, including changes in the levels of carbohydrates, ketone bodies, eicosanoids, phospholipids, and amino acids, which are consistent with the scientific data available to date. The CBM enabled the separation of diabetic patients according to their metabolic metabotypes, providing both a general overview of their metabolic alterations and detailing their individual metabolic characteristics. It was concluded that the CBM is a precise and clinically applicable test for assessing an individual's metabolic status in diabetes mellitus for diagnostic and treatment purposes.

Indexed as

bloodclinical blood testsdiabetes mellitusdiagnosticsimpaired glucose tolerancemass spectrometrymetabogrammetabolomicspersonalized metabolomics

Identifiers

PMID38535328
PMCPMC10972189
OpenAlexW4392926012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.