ArticleMetabolites2024
Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals-The Uric Acid Right for Heart Health (URRAH) Project.
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Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Serum uric acid and its metabolism-a vital factor in the inflammatory transformation of cancer.Journal of advanced research · 2026Review
- Association between serum uric acid to serum creatinine ratio and in-hospital mortality in patients with severe acute pancreatitis: a retrospective study.BMC gastroenterology · 2025Article
- Hyperuricemia in Chronic Kidney Disease: Emerging Pathophysiology and a Novel Therapeutic Strategy.International journal of molecular sciences · 2025Review
- Review
- The Role of Serum Uric Acid and Serum Creatinine Ratio as Possible Markers of Autonomic Dysfunction and Left Ventricular Mass Index in Atherosclerotic Renal Artery Stenosis.Journal of cardiovascular development and disease · 2025Article
- Serum Uric Acid/Serum Creatinine Ratio and Chronic Vascular Lesions on Renal Biopsy: A Retrospective Observational Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Observational
- Insights into renal damage in hyperuricemia: Focus on renal protection (Review).Molecular medicine reports · 2025Review
- Clinical outcomes in patients with cardiorenal multimorbidity: the role of serum uric acid/serum creatinine ratio.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study.Lipids in health and disease · 2025Article
- Serum uric acid to creatinine ratio and long-term target vessel events in diabetes patients undergoing PCI with drug-eluting stents implantation: a retrospective study.Frontiers in endocrinology · 2025Article
- High serum uric acid/creatinine ratio is a useful predictor of hypertension among Japanese community-dwelling persons.Clinical hypertension · 2025Article
- Nonlinear association between the serum uric acid-to-creatinine ratio and all cause mortality in patients with hypertension: a ten-year cohort study using the NHANES database.Scientific reports · 2024Article
- Association Between Serum Uric Acid Levels and Metabolic-Associated Fatty Liver Disease in Southeast China: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
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Authors and funding
46 authors at 20 institutions in 2 countries.
Lanfranco D'EliaDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-1782-0211
Maria MasulliDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.
Pietro CirilloNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
Agostino VirdisDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6994-0223
Edoardo CasigliaStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0002-0003-3289
Valerie TikhonoffDepartment of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-7846-0101
Fabio AngeliDepartment of Medicine and Technological Innovation (DiMIT), University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-4925-7985
Carlo Maria BarbagalloBiomedical Department of Internal Medicine and Specialistics, University of Palermo, 90100 Palermo, Italy.ORCID 0000-0002-4114-038X
Michele BombelliInternal Medicine, Pio XI Hospital of Desio, ASST Brianza, University of Milano-Bicocca, 20871 Vimercate, Italy.
Federica CappelliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Rosario CianciDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7886-8027
Michele CiccarelliDepartment of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy.ORCID 0000-0003-2379-1960
Arrigo F G CiceroHypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-4367-3884
Massimo CirilloDepartment of Public Health, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-6409-3504
Raffaella Dell'OroClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Giovambattista DesideriDepartment of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Claudio FerriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3594-2503
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
Cristina GiannattasioCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.
Guido GrassiClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Guido IaccarinoDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-8997-835X
Luciano LippaItalian Society of General Medicine (SIMG), 67051 Avezzano, Italy.
Francesca MallamaciDepartment of Nephrology, Dialysis and Transplantation GOM "Bianchi-Melacrino-Morelli", 89133 Reggio Calabria, Italy.
Alessandro MalobertiCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.ORCID 0000-0002-2612-6264
Stefano MasiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7591-3686
Alberto MazzaDepartment of Internal Medicine, Santa Maria Della Misericordia General Hospital, AULSS 5 Polesana, 45100 Rovigo, Italy.
Alessandro MengozziDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Maria Lorenza MuiesanDepartment of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-4007-9441
Pietro NazzaroDepartment of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Neurosciences and Sense Organs, University of Bari Medical School, 70122 Bari, Italy.
Paolo PalatiniStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-5402-4946
Gianfranco ParatiSan Luca Hospital, IRCCS, Istituto Auxologico Italiano, 20149 Milan, Italy.ORCID 0000-0001-9402-7439
Roberto PontremoliDipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, 16132 Genova, Italy.ORCID 0000-0003-1238-872X
Fosca Quarti-TrevanoClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Marcello RattazziMedicina Interna 1°, Ca' Foncello, Department of Medicine-DIMED, University of Padova Hospital, 31100 Treviso, Italy.
Gianpaolo ReboldiDepartment of Medicine and Surgery, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-9877-0702
Giulia RivasiDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.ORCID 0000-0002-2736-2242
Elisa RussoDipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, 16132 Genova, Italy.ORCID 0000-0003-1279-3178
Massimo SalvettiDepartment of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0001-8101-1374
Giuliano TocciDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00189 Rome, Italy.ORCID 0000-0002-0635-4921
Andrea UngarDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.
Paolo VerdecchiaHospital S. Maria della Misericordia, 06100 Perugia, Italy.
Francesca ViazziDipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, 16132 Genova, Italy.ORCID 0000-0003-4219-7043
Massimo VolpeDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00189 Rome, Italy.
Claudio BorghiHypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-8039-8781
Ferruccio GallettiDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.
Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
University of Milano-Bicocca · ITUniversity of Naples Federico II · ITUniversity of Pisa · ITOspedale Policlinico San Martino · ITUniversity of Bari Aldo Moro · ITUniversity of Padua · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda USL di Bologna · ITSapienza University of Rome · ITUniversity of Brescia · ITUniversity of Florence · ITAzienda ospedaliera "Bianchi-Melacrino-Morelli" · ITCa' Foncello Hospital · ITCTO Andrea Alesini · ITIRCCS Istituto Auxologico Italiano · ITIRCCS Ospedale San Raffaele · ITOspedale Santa Maria della Misericordia di Rovigo · ITSocietà Italiana di Medicina Generale · ITUniversity of Insubria · ITUniversity of L'Aquila · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict CV mortality at 5.35 Units. Therefore, given that no SUA/sCr ratio threshold for CV risk has been identified for patients with diabetes, we aimed to assess the relationship between this index and CV mortality and to validate this threshold in the URRAH subpopulation with diabetes; the URRAH participants with diabetes were studied (
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cardiovascularcreatininediabetesuric acid
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