Evidence map›Paper›PMID 38535182›Full record

ReviewJournal of fungi (Basel, Switzerland)2024

The Host Response to Coccidioidomycosis.

Theo N Kirkland, Chiung-Yu Hung, Lisa F Shubitz, Sinem Beyhan, Joshua Fierer

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Immunomodulation in the Treatment of Disseminated Coccidioidomycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Article
  3. Review
  4. Type-2 immune skewing in patients with disseminated coccidioidomycosis.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Theo N KirklandDepartment of Medicine, Division of Infectious Disease, San Diego School of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0001-7908-7302
Chiung-Yu HungSouth Texas Center for Emerging Infectious Disease, Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0003-1091-3420
Lisa F ShubitzValley Fever Center for Excellence, University of Arizona, Tucson, AZ 85724, USA.
Sinem BeyhanDepartment of Medicine, Division of Infectious Disease, San Diego School of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-0906-7538
Joshua FiererDepartment of Medicine, Division of Infectious Disease, San Diego School of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-9230-5279
University of California San Diego · USJ. Craig Venter Institute · USTexas Center for Infectious Disease · USUniversity of Arizona · US

Funding

Innate immune mechanisms of the host response to CoccidioidesU19AI166059 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAROLD M HOFFMAN · 2022 to 2026
$10.0M
Screening Repurposing Libraries for the Identification of Drugs with Novel anti-Coccidioidal ActivityU19AI166761 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI CHIUNG-YU HUNG · 2022 to 2026
$8.1M
Interplay between the heat shock response and histidine kinase pathways in the thermally dimorphic fungal pathogen Histoplasma capsulatumR01AI137418 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI BEYHAN, SINEM · 2018 to 2023
$2.4M
Development of a multivalent vaccine against Coccidioides infectionR01AI135005 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI135005NIAID NIH HHS R01 AI137418NIAID NIH HHS U19 AI166059NIAID NIH HHS U19 AI166761
6 · The paper itself

Abstract

Coccidioidomycosis is an important fungal disease that is found in many desert regions of the western hemisphere. The inhaled organisms are highly pathogenic, but only half of infected, immunologically intact people develop symptomatic pneumonia; most symptomatic infections resolve spontaneously, although some resolve very slowly. Furthermore, second infections are very rare and natural immunity after infection is robust. Therefore, the host response to this organism is very effective at resolving the infection in most cases and immunizing to prevent second infections. People who are immunocompromised are much more likely to develop disseminated infection. This is a comprehensive review of the innate and acquired immune responses to

Indexed as

acquired immunitycoccidioidomycosisdendritic cellsgeneticsimmunityinnate immunitymacrophagesvaccines

Identifiers

PMID38535182
PMCPMC10971205
OpenAlexW4392163654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.