Limited Role of the Apparent Diffusion Coefficient (ADC) for Tumor Grade and Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma.

Deniece M Riviere, Marnix C Maas, Lodewijk A A Brosens, Martijn W J Stommel, Cornelis J H M van Laarhoven, John J Hermans

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Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

6 authors.

Deniece M RiviereDepartment of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4330-7902

Marnix C MaasDepartment of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Lodewijk A A BrosensDepartment of Pathology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Martijn W J StommelDepartment of Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Cornelis J H M van LaarhovenDepartment of Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

John J HermansDepartment of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-9207-0548

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the relationship between apparent diffusion coefficient (ADC) values in pancreatic ductal adenocarcinoma (PDAC) and tumor grades based on WHO, Adsay, and Kalimuthu classifications, using whole-mount pancreatectomy specimens. If glandular formation plays a key role in the degree of diffusion restriction, diffusion-weighted imaging could facilitate non-invasive grading of PDAC. A freehand region of interest (ROI) was drawn along tumor borders on the preoperative ADC map in each tumor-containing slice. Resection specimens were retrospectively graded according to WHO, Adsay, and Kalimuthu classifications and correlated with overall survival and the 10th percentile of whole-volume ADC values. Findings from 40 patients (23 male, median age 67) showed no correlation between ADC p10 values and WHO differentiation (

Indexed as

ADCdiffusiongradingMRIpancreatic ductal adenocarcinoma

Identifiers

PMID38534994

DOI10.3390/diagnostics14060573

PMCPMC10968963

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