Evidence map›Paper›PMID 38534950›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Safety and Feasibility of Combining On-Demand Selective Locoregional Treatment with First-Line Atezolizumab Plus Bevacizumab for Patients with Unresectable Hepatocellular Carcinoma.

Tasuku Nakabori, Sena Higashi, Yutaro Abe, Kaori Mukai, Toshiki Ikawa, Koji Konishi, Noboru Maeda, Katsuyuki Nakanishi, Shinichiro Hasegawa, Hiroshi Wada and 1 more

Open access · goldAbstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tasuku NakaboriDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0002-9486-850X
Sena HigashiDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Yutaro AbeDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Kaori MukaiDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Toshiki IkawaDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.ORCID 0000-0001-9097-0227
Koji KonishiDepartment of Radiation Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Noboru MaedaDepartment of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Katsuyuki NakanishiDepartment of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Shinichiro HasegawaDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Hiroshi WadaDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Kazuyoshi OhkawaDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan.
Osaka International Cancer Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various locoregional treatments for localized hepatocellular carcinoma (HCC) have been developed. This retrospective study investigated the safety and feasibility of combining on-demand selective locoregional treatment for residual lesions after tumor shrinkage (complete response [CR] oriented) or for solitary or few drug-resistant lesions (progressive disease (PD) salvage) with first-line atezolizumab plus bevacizumab (atezo/bev) for unresectable HCC. Twenty-nine patients with unresectable HCC were included. Fourteen locoregional treatments were performed (CR oriented, 7; PD salvage, 7) in ten patients in the combination-therapy group. All patients in the combination-therapy group successfully achieved a CR or PD salvage status after the planned locoregional treatment. The objective response rate of the combination-therapy group (80.0%) was higher than that of the atezo/bev alone group (21.1%;

Indexed as

Antibodies, Monoclonal, HumanizedCarcinoma, HepatocellularLiver NeoplasmsBevacizumabFeasibility StudiesHumansRetrospective StudiesAntibodies, Monoclonal, HumanizedatezolizumabBevacizumabatezolizumab plus bevacizumabcombination therapyhepatocellular carcinomalocoregional treatmentradiofrequency ablationstereotactic body radiotherapysurgical resectiontransarterial chemoembolization

Identifiers

PMID38534950
PMCPMC10969074
OpenAlexW4392914428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.