Evidence map›Paper›PMID 38534921›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Spatially Resolved Microglia/Macrophages in Recurrent Glioblastomas Overexpress Fatty Acid Metabolism and Phagocytic Genes.

Akshitkumar M Mistry, Jonah Daneshmand, SeonYeong Jamie Seo, Norman L Lehman, Donald M Miller, Dylan A Goodin, Hermann B Frieboes, Joseph Chen, Adrianna Masters, Brian J Williams and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Akshitkumar M MistryDepartment of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-7918-5153
Jonah DaneshmandDepartment of Bioinformatics, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-7101-7542
SeonYeong Jamie SeoDepartment of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.
Norman L LehmanDepartments of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY 40202, USA.
Donald M MillerBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Dylan A GoodinDepartment of Bioengineering, University of Louisville, Louisville, KY 40202, USA.
Hermann B FrieboesBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Joseph ChenDepartment of Bioengineering, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-7585-0662
Adrianna MastersBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Brian J WilliamsDepartment of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.
Kavitha YaddanapudiBrown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · US

Funding

Henry Vogt Endowment Funds N/A
6 · The paper itself

Abstract

backgroundGlioblastoma (GBM) tumors are rich in tumor-associated microglia/macrophages. Changes associated with treatment in this specific cell population are poorly understood. Therefore, we studied changes in gene expression of tumor-associated microglia/macrophages (Iba1+) cells in de novo versus recurrent GBMs.

methodsNanoString GeoMx

resultsUnsupervised analyses of the NanoString GeoMx

conclusionTumor-associated microglia/macrophages in recurrent GBM overexpress genes involved in fatty acid/lipid metabolism. Further investigation is needed to fully delineate the role of PLD phospholipases in GBM progression.

Indexed as

Brain NeoplasmsGlioblastomaFatty AcidsHumansMacrophagesMicrogliaNeoplasm Recurrence, LocalFatty Acidsfatty acidglioblastomamacrophagesmicrogliarecurrence

Identifiers

PMID38534921
PMCPMC10968993
OpenAlexW4392124995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.