Evidence map›Paper›PMID 38534647›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Synthesis and Characterization of New N-acyl Hydrazone Derivatives of Carprofen as Potential Tuberculostatic Agents.

Ilinca Margareta Vlad, Diana Camelia Nuță, Miron Theodor Căproiu, Florea Dumitrașcu, Eleonóra Kapronczai, Georgiana Ramona Mük, Speranta Avram, Adelina Gabriela Niculescu, Irina Zarafu, Vanesa Alexandra Ciorobescu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Synthesis and structure of (Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
  3. Article
  4. Review
  5. Evaluation of hydrazone andJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ilinca Margareta VladDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no. 6, 020956 Bucharest, Romania.
Diana Camelia NuțăDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no. 6, 020956 Bucharest, Romania.ORCID 0000-0002-7685-3291
Miron Theodor Căproiu"C. D. Nenitzescu" Institute of Organic and Supramolecular Chemistry, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Florea Dumitrașcu"C. D. Nenitzescu" Institute of Organic and Supramolecular Chemistry, 202B Splaiul Independenței, 060023 Bucharest, Romania.
Eleonóra KapronczaiDepartment of Chemistry, Supramolecular Organic and Organometallic Chemistry Centre, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany János, 400028 Cluj-Napoca, Romania.ORCID 0000-0002-4912-0586
Georgiana Ramona MükFaculty of Biology, University of Bucharest, Splaiul Independenței 91-95, 050095 Bucharest, Romania.ORCID 0009-0004-9848-3115
Speranta AvramFaculty of Biology, University of Bucharest, Splaiul Independenței 91-95, 050095 Bucharest, Romania.
Adelina Gabriela NiculescuResearch Institute of the University of Bucharest, Sos. Panduri 90-92, 050095 Bucharest, Romania.ORCID 0000-0001-8968-504X
Irina ZarafuDepartment of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania.ORCID 0000-0002-9144-5528
Vanesa Alexandra CiorobescuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no. 6, 020956 Bucharest, Romania.
Ana Maria BrezeanuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no. 6, 020956 Bucharest, Romania.
Carmen LimbanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no. 6, 020956 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · ROBabeș-Bolyai University · RO

Funding

Ministerul Cercetării și Inovării 33_PFE/2021-29477/5.10.2022
6 · The paper itself

Abstract

N-acyl hydrazone (NAH) is recognized as a promising framework in drug design due to its versatility, straightforward synthesis, and attractive range of biological activities, including antimicrobial, antitumoral, analgesic, and anti-inflammatory properties. In the global context of increasing resistance of pathogenic bacteria to antibiotics, NAHs represent potential solutions for developing improved treatment alternatives. Therefore, this research introduces six novel derivatives of (

Indexed as

FT-IR spectral dataHRMS analysismicrowave synthesisN-acyl hydrazone derivativesNMR analysistuberculostatic activity

Identifiers

PMID38534647
PMCPMC10967372
OpenAlexW4392101542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.