Evidence map›Paper›PMID 38534523›Full record

ArticleBioengineering (Basel, Switzerland)2024

Profile of a Multivariate Observation under Destructive Sampling-A Monte Carlo Approach to a Case of Spina Bifida.

Tianyuan Guan, Rigwed Tatu, Koffi Wima, Marc Oria, Jose L Peiro, Chia-Ying Lin, Marepalli B Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianyuan GuanCollege of Public Health, Kent State University, Kent, OH 44242, USA.ORCID 0000-0002-7403-4663
Rigwed TatuThe Center for Fetal and Placental Research, Pediatric General and Thoracic Surgery Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Koffi WimaDivision of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, OH 45221, USA.
Marc OriaThe Center for Fetal and Placental Research, Pediatric General and Thoracic Surgery Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Jose L PeiroThe Center for Fetal and Placental Research, Pediatric General and Thoracic Surgery Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Chia-Ying LinOrthopedic Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Marepalli B RaoDivision of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, OH 45221, USA.

Funding

A Novel Smart Patch for the Fetoscopic Procedure to Repair Spina BifidaR01NS103992 · NINDS · UNIVERSITY OF CINCINNATI · PI LIN, CHIA-YING JAMES, PEIRO IBANEZ, JOSE LUIS · 2019 to 2023
$2.4M
NINDS NIH HHS R01 NS103992
6 · The paper itself

Abstract

A biodegradable hybrid polymer patch was invented at the University of Cincinnati to cover gaps on the skin over the spinal column of a growing fetus, characterized by the medical condition spina bifida. The inserted patch faces amniotic fluid (AF) on one side and cerebrospinal fluid on the other side. The goal is to provide a profile of the roughness of a patch over time at 0, 4, 8, 12, and 16 weeks with a 95% confidence band. The patch is soaked in a test tube filled with either amniotic fluid (AF) or phosphate-buffered saline (PBS) in the lab. If roughness is measured at any time point for a patch, the patch is destroyed. Thus, it is impossible to measure roughness at all weeks of interest for any patch. It is important to assess the roughness of a patch because the rougher the patch is, the faster the skin grows under the patch. We use a model-based approach with Monte Carlo simulations to estimate the profile over time with a 95% confidence band. The roughness profiles are similar with both liquids. The profile can be used as a template for future experiments on the composition of patches.

Indexed as

birth defectsdestructive samplinghybrid polymer patchesmultivariate normal distribution

Identifiers

PMID38534523
PMCPMC10967902

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.