Evidence map›Paper›PMID 38534378›Full record

ArticleCells2024

Deep Learning Powered Identification of Differentiated Early Mesoderm Cells from Pluripotent Stem Cells.

Sakib Mohammad, Arpan Roy, Andreas Karatzas, Sydney L Sarver, Iraklis Anagnostopoulos, Farhan Chowdhury

Open access · goldAbstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sakib MohammadSchool of Electrical, Computer, and Biomedical Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.ORCID 0009-0000-0692-2426
Arpan RoySchool of Mechanical, Aerospace, and Materials Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.
Andreas KaratzasSchool of Electrical, Computer, and Biomedical Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.ORCID 0000-0001-6804-135X
Sydney L SarverSchool of Mechanical, Aerospace, and Materials Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.
Iraklis AnagnostopoulosSchool of Electrical, Computer, and Biomedical Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.ORCID 0000-0003-0985-3045
Farhan ChowdhurySchool of Electrical, Computer, and Biomedical Engineering, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.ORCID 0000-0003-1527-2677
Southern Illinois University Carbondale · US

Funding

Single-molecule approaches to study epiblast stem cell fate decisionR15GM140448 · NIGMS · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI Farhan H Chowdhury · 2021 to 2026
$1.1M
NIGMS NIH HHS R15 GM140448NIH HHS 1R15GM140448
6 · The paper itself

Abstract

Pluripotent stem cells can be differentiated into all three germ-layers including ecto-, endo-, and mesoderm in vitro. However, the early identification and rapid characterization of each germ-layer in response to chemical and physical induction of differentiation is limited. This is a long-standing issue for rapid and high-throughput screening to determine lineage specification efficiency. Here, we present deep learning (DL) methodologies for predicting and classifying early mesoderm cells differentiated from embryoid bodies (EBs) based on cellular and nuclear morphologies. Using a transgenic murine embryonic stem cell (mESC) line, namely OGTR1, we validated the upregulation of mesodermal genes (

Indexed as

Deep LearningPluripotent Stem CellsAnimalsCell DifferentiationGerm LayersMesodermMicecell and nuclear morphologiesdeep learningembryoid bodiesembryonic stem cellsmesoderm

Identifiers

PMID38534378
PMCPMC10969030
OpenAlexW4392913302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.