Evidence map›Paper›PMID 38534254›Full record

ArticleBiosensors2024

Advancing Point-of-Care Diagnosis: Digitalizing Combinatorial Biomarker Signals for Lupus Nephritis.

Jiechang Guo, Aygun Teymur, Chenling Tang, Ramesh Saxena, Tianfu Wu

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiechang GuoDepartment of Biomedical Engineering, University of Houston, Houston, TX 77024, USA.
Aygun TeymurDepartment of Biomedical Engineering, University of Houston, Houston, TX 77024, USA.
Chenling TangDepartment of Biomedical Engineering, University of Houston, Houston, TX 77024, USA.ORCID 0000-0001-9037-1179
Ramesh SaxenaDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5722-9509
Tianfu WuDepartment of Biomedical Engineering, University of Houston, Houston, TX 77024, USA.ORCID 0000-0003-4406-1449
University of Houston · USSouthwestern Medical Center · US

Funding

A biomarker panel based smart mini-array system for the homecare of autoimmune kidney diseasesR01AG062987 · NIA · UNIVERSITY OF HOUSTON · PI WU, TIANFU · 2019 to 2023
$2.2M
NIA NIH HHS R01 AG062987NIH HHS R01AG062987
6 · The paper itself

Abstract

To improve the efficiency and patient coverage of the current healthcare system, user-friendly novel homecare devices are urgently needed. In this work, we developed a smartphone-based analyzing and reporting system (SBARS) for biomarker detection in lupus nephritis (LN). This system offers a cost-effective alternative to traditional, expensive large equipment in signal detection and quantification. This innovative approach involves using a portable and affordable microscopic reader to capture biomarker signals. Through smartphone-based image processing techniques, the intensity of each biomarker signal is analyzed. This system exhibited comparable performance to a commercial Genepix scanner in the detection of two potential novel biomarkers of LN, VISG4 and TNFRSF1b. Importantly, this smartphone-based analyzing and reporting system allows for discriminating LN patients with active renal disease from healthy controls with the area-under-the-curve (AUC) value = 0.9 for TNFRSF1b and 1.0 for VSIG4, respectively, indicating high predictive accuracy.

Indexed as

Lupus NephritisBiomarkersHumansPoint-of-Care SystemsBiomarkersbiomarkerclinical diagnosticscolorimetric microarrayimage processingpoint-of-care testingsmartphone application

Identifiers

PMID38534254
PMCPMC10968647
OpenAlexW4392912149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.