Evidence map›Paper›PMID 38534048›Full record

Observational studyJournal of diabetes investigation2024

The impact of handgrip strength and waist circumference on glycemic control: Prospective, observational study using outpatient clinical data in Japanese patients with type 2 diabetes mellitus.

Shuhei Nakanishi, Masashi Shimoda, Tomohiko Kimura, Junpei Sanada, Yoshiro Fushimi, Yuichiro Iwamoto, Hideyuki Iwamoto, Kazunori Dan, Tomoatsu Mune, Kohei Kaku and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of diabetes investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuhei NakanishiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0003-2640-9632
Masashi ShimodaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0002-4223-9613
Tomohiko KimuraDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0003-3986-9494
Junpei SanadaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Yoshiro FushimiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Yuichiro IwamotoDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0001-8162-359X
Hideyuki IwamotoDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Kazunori DanDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Tomoatsu MuneDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Kohei KakuDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0003-1574-0565
Hideaki KanetoDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0001-7898-1943

Funding

Japan Society for the Promotion of Science 22K11488Kawasaki Medical School R05B-015
6 · The paper itself

Abstract

introductionLoss of muscle mass and the accumulation of visceral fat are known risk factors for the deterioration of glycemic control in type 2 diabetes mellitus. This study looked at the effects of such factors on glycemic control in Japanese patients with type 2 diabetes mellitus in the form of handgrip strength (HGS) and waist circumference (WC). MATERIALS AND

methodsIn this prospective, observational study, 233 patients with type 2 diabetes mellitus and a HbA1c level of ≥7.0% were followed for around 1 year, during which time they were studied for an understanding of the association between handgrip strength, waist circumference, and glycemic control (HbA1c <7.0%). Hazard ratios (HRs) and 95% confidence intervals (CIs) for glycemic control improvement by Cox hazards models were analyzed for handgrip strength and waist circumference.

resultsCompared with the low tertile, patients in the middle and high tertiles of handgrip strength when adjustment was carried out for waist circumference were 2.117 (1.142-3.924) and 4.670 (2.526-8.632), respectively. The HRs of patients in the middle and high tertiles of WC when adjustment was made for HGS were 0.442 (0.269-0.725) and 0.339 (0.191-0.604), respectively. Within the low, middle, and high HGS tertiles, the HRs for WC were 0.863 (0.797-0.934), 0.940 (0.899-0.982), and 1.009 (0.984-1.035), respectively, although the HRs for HGS within each WC tertile remained significant.

conclusionsHandgrip strength and waist circumference demonstrated independent associations for glycemic control, but the effect of waist circumference appeared to be at least partially canceled out by increased handgrip strength. The data suggest that handgrip strength might help to mitigate the negative impact of waist circumference on glycemic control.

Indexed as

Diabetes Mellitus, Type 2Glycemic ControlHand StrengthWaist CircumferenceAgedBlood GlucoseEast Asian PeopleFemaleGlycated HemoglobinHumansJapanMaleMiddle AgedOutpatientsProspective StudiesBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHandgrip strengthHbA1cWaist circumference

Identifiers

PMID38534048
PMCPMC11215675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.