SynthesisJournal of the American Heart Association2024
Conservative Versus Surgical Therapy in Patients With Infective Endocarditis and Surgical Indication-Meta-Analysis of Reconstructed Time-to-Event Data.
Synthesis in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Sex Differences in Clinical Outcomes and Loss of Life Expectancy After Aortic Valve Surgery for Infective Endocarditis: A SWEDEHEART Study.Journal of the American Heart Association · 2026Observational
- Neurological Complications and Surgical Outcomes in Infective Endocarditis.Journal of the American Heart Association · 2026Article
- Nomogram for predicting 30-day mortality in patients with infective endocarditis: a retrospective study.BMC medical informatics and decision making · 2026Article
- Article
- Delayed Diagnosis of Infective Endocarditis-Analysis of an Endocarditis Network.Journal of clinical medicine · 2026Article
- Scratches of danger: fromEuropean heart journal. Case reports · 2026Article
- Progression of Untreated Mild Aortic Valve Disease in Patients Undergoing Rheumatic Mitral Valve Surgery: A Meta-Analysis of Reconstructed Time-to-Event Data.Journal of cardiovascular development and disease · 2025Review
- Surgical and Clinical Aspects Associated with Double-Valve Infective Endocarditis.Journal of clinical medicine · 2025Article
- Article
- A case ofIDCases · 2025Article
- Impact of an Infective Endocarditis Team on Management and Outcomes: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- The Influence of Characteristics and Indexes (NLR, PNI, and SII) Evaluated at Admission on the Mortality Prediction of Infectious Endocarditis Patients.International journal of general medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfective endocarditis represents a life-threatening disease with high mortality rates. A fraction of patients receives exclusively conservative antibiotic treatment due to their comorbidities and high operative risk, despite fulfilling criteria for surgical therapy. The aim of the present study is to compare outcomes in patients with infective endocarditis and indication for surgical therapy in those who underwent or did not undergo valve surgery. METHODS AND
resultsThree databases were systematically assessed. A pooled analysis of Kaplan-Meier-derived reconstructed time-to-event data from studies with longer follow-up comparing conservative and surgical treatment was performed. A landmark analysis to further elucidate the effect of surgical intervention on mortality was carried out. Four studies with 3003 patients and median follow-up time of 7.6 months were included. Overall, patients with an indication for surgery who were surgically treated had a significantly lower risk of mortality compared with patients who received conservative treatment (hazard ratio [HR], 0.27 [95% CI, 0.24-0.31],
conclusionsBased on the findings of this study-level meta-analysis, patients with infective endocarditis and formal indication for surgical intervention who underwent surgery are associated with a lower risk of short- and long-term mortality when compared with conservative treatment.
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