Evidence map›Paper›PMID 38533539›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle.

Tohru Hosoyama, Minako Kawai-Takaishi, Hiroki Iida, Yoko Yamamoto, Yuko Nakamichi, Tsuyoshi Watanabe, Marie Takemura, Shigeaki Kato, Akiyoshi Uezumi, Yasumoto Matsui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tohru HosoyamaDepartment of Musculoskeletal Disease, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID 0000-0002-1825-6923
Minako Kawai-TakaishiDepartment of Musculoskeletal Disease, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Hiroki IidaDepartment of Musculoskeletal Disease, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Yoko YamamotoDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Yuko NakamichiInstitute for Oral Science, Matsumoto Dental University, Nagano, Japan.
Tsuyoshi WatanabeCenter for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology, Obu, Japan.
Marie TakemuraCenter for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology, Obu, Japan.
Shigeaki KatoGraduate School of Life Science and Engineering, Iryo Sosei University, Fukushima, Japan.
Akiyoshi UezumiMedical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Yasumoto MatsuiCenter for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology, Obu, Japan.
National Center for Geriatrics and Gerontology · JPJyoban Hospital of Tokiwa Foundation · JPKyushu University · JPMatsumoto Dental University · JPThe University of Tokyo · JP

Funding

Japanese Ministry of Health, Labour and Welfare 21-44Japan Society for the Promotion of Science 21K09289Tanita Healthy Weight Community Promotion Research GrantZenyaku-Kogyo Research Grant
6 · The paper itself

Abstract

backgroundRecent studies have indicated the importance of muscle quality in addition to muscle quantity in sarcopenia pathophysiology. Intramuscular adipose tissue (IMAT), which originates from mesenchymal progenitors (MPs) in adult skeletal muscle, is a key factor affecting muscle quality in older adults, suggesting that controlling IMAT formation is a promising therapeutic strategy for sarcopenia. However, the molecular mechanism underlying IMAT formation in older adults has not been clarified. We recently found that the vitamin D receptor (VDR) is highly expressed in MPs in comparison to myotubes (P = 0.028, N = 3), indicating a potential role of vitamin D signalling in MPs. In this study, we aimed to clarify the role of vitamin D signalling in MP kinetics, with a focus on adipogenesis.

methodsMPs isolated from mouse skeletal muscles were subjected to adipogenic differentiation conditions with or without vitamin D (1α,25(OH)2D3, 100 nM) for 7 days, and adipogenicity was evaluated based on adipogenic marker expression. For in vivo analysis, tamoxifen-inducible MP-specific VDR-deficient (Vdr

resultsVitamin D treatment nearly completely inhibited adipogenesis of MPs through Runx1-mediated transcriptional modifications of early adipogenic factors such as PPARγ (P = 0.0031) and C/EBPα (P = 0.0027), whereas VDR-deficient MPs derived from Vdr

conclusionsVitamin D signalling is important to prevent fate decision of MPs towards the adipogenic lineage. As vitamin D levels decline with age, our data indicate that decreased vitamin D levels may be one of the causes of IMAT formation in older adults, and vitamin D signalling may be a novel therapeutic target for sarcopenia.

Indexed as

Mesenchymal Stem CellsMuscle, SkeletalReceptors, CalcitriolSignal TransductionVitamin DAdipogenesisAdipose TissueAnimalsCell DifferentiationDisease Models, AnimalMaleMiceReceptors, CalcitriolVitamin DInter/intramuscular adipose tissueMesenchymal progenitorSarcopeniaVDRVitamin D

Identifiers

PMID38533539
PMCPMC11154772
OpenAlexW4393231852

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.