A Neural Biomarker for Hallucinations: Medial Prefrontal Aberrations in Neural Connectivity Predict Self-Agency Deficits and Hallucination Severity in Schizophrenia.

Shalaila S Haas, Leighton B N Hinkley, Melissa Fisher, Sophia Vinogradov, Srikantan Nagarajan, Karuna Subramaniam

Abstract read

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Article in Journal of brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025
Article
Reduced neural connectivity in the caudate anterior head predicts hallucination severity in schizophrenia.Schizophrenia research · 2023
Article

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5 · Who and what money

Authors and funding

6 authors.

Shalaila S HaasDepartment of Psychiatry, Icahn School of Medicine Mount Sinai, NY-10029, USA.

Leighton B N HinkleyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA- 94143, USA.

Melissa FisherDepartment of Psychiatry, University of Minnesota, Minneapolis, MN-55414, USA.

Sophia VinogradovDepartment of Psychiatry, University of Minnesota, Minneapolis, MN-55414, USA.

Srikantan NagarajanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA- 94143, USA.

Karuna SubramaniamDepartment of Psychiatry, University of California, San Francisco, CA-94143, USA.

Funding

Causal Role of Medial Prefrontal Neural Activity in Self-Agency in Schizophrenia (Admin Suppl)R01MH122897 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUBRAMANIAM, KARUNA · 2020 to 2024

$4.4M

NIMH NIH HHS R01 MH122897

6 · The paper itself

Abstract

Prior studies have shown that the medial prefrontal cortex (mPFC) represents one neural substrate that mediates judgments of self-agency (i.e., the awareness that 'I am the originator of my actions'). Patients with schizophrenia (SZ) manifest cardinal self-agency deficits that contribute to debilitating psychotic symptoms (e.g. hallucinations) and distort reality monitoring. This is the first study in which we examine across 2 SZ samples, the mPFC site that underlies self-agency deficits during an explicit reality-monitoring task (i.e., while subjects distinguish self-generated information from externally-derived information) in one SZ sample, and link intrinsic functional connectivity (iFC) during rest within this

Indexed as

hallucinationsmedial prefrontal cortexreality monitoringresting-state fMRIschizophreniaself-agency

Identifiers

PMID38533396

PMCPMC10964909

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